Bile acids profile and transition from NAFLD into NASH
Metabolomic studies suggest plasma levels of bile acids are elevated amongst subjects with NAFLD compared to healthy controls. However, it remains unclear.....
Search Results for Fibrosis
Pathophysiological roles of cell death in NASH
The conventional detection of necrosis in vivo is not currently available, whereas the detection method for apoptosis has been relatively well-established ....
Culture of mouse liver ductal organoids
3D organoid culture has become a powerful tool and model for various human diseases, including NASH. The hepatic progenitor cells can be induced to form hepatic organoids, .....
Purification and isolation of hepatic stellate cells
In an activated form, human hepatic stellate cells are the drivers of fibrosis following chronic liver injury. In NASH specifically, activated human hepatic stellate cells are drivers of induction and progression of fibrogenesis. .....
NASH Management in 2022: benefits of lifestyle recommendations, including nutrition and exercise
Prof. Stephen Harrison (USA) discusses state of the art management of non-alcoholic steatohepatitis (NASH) in 2022. He focuses on the benefits of lifestyle recommendations, including nutrition and exercise. He shows that weight loss is associated with NASH resolution and fibrosis regression over time following bariatric surgery in patients with severe obesity and NASH.
Pathogenesis of NASH and dynamic changes in liver macrophages
Macrophage-mediated inflammation is critical in the pathogenesis of NASH. T-cell immunoglobulin domain and mucin domain-4 (TIM-4) is selectively expressed on antigen-presenting cells and modulates various immune responses. However, the role of TIM-4 expressed by Kupffer cells in liver fibrosis remains unclear....
NIT for screening, referral & diagnosis of NAFLD
Liver fibrosis is the major driver in liver disease progression. Prof. Romero-Gómez, Spain, reviews on NoninvasiveTests - NITs for screening, referral, and diagnosis of nonalcoholic fatty liver disease.
Coffee consumption and NAFLD: A systematic review
The effects of coffee consumption on hepatic outcomes are controversial. This study investigated the associations between coffee consumption and the incidence of NAFLD in the general population and the reduction of liver fibrosis among patients with NAFLD...
NAFLD and CV disease among US adults
In this study, S. Ciardullo et al. (Università degli Studi di Milano Bicocca, Italy) present a population-based cross-sectional study including 2734 US adults using data from the 2017-2018 cycle of the National Health and Nutrition Examination Survey The authors show that “patients with NAFLD have....
NASH: prevalence and incidence of non-liver comorbidities in South Korea
Using a meta-analytic approach, J. Park et al. (Santa Clara Valley Medical Center, San Jose, CA, USA) aimed to describe NAFLD incidence and prevalence, NAFLD fibrosis prevalence, and incidence of non-liver comorbidities. In this study, the overall prevalence of NAFLD was 31.46% with an incidence rate of 42.8 per 1,000 person-years...
NASH: a complex disease
In this review, J. L. Fraile et al. (University of Aberdeen, UK) have performed an exhaustive review of the current therapeutic landscape (drug classes, biologics vs small molecules, and target molecules) for NASH. Regarding lanifibranor, the authors stated, “it’s an oral small molecule that activates...
Interactions between gut microbiota and PPARs in NAFLD
Dr. Nicolas Lanthier (Belgium) reviews the interaction between the gut microbiota and PPARs in NAFLD. He discusses the microbiota and its link to NAFLD and IR, where he explains the key role of the gut microbes in the metabolism of their host and highlights how liver becomes the first organ to be exposed to gut changes.