Unhealthy lifestyles and diet contribute to the increasing prevalence of NAFLD/NASH

It is estimated that 25% of the global adult population is potentially affected by non-alcoholic fatty liver disease (NAFLD), with the highest prevalence in the Middle East and South America and the lowest in Africa. In the United States, approximately 25% of NAFLD patients have NASH, of which one-quarter have cirrhosis. Furthermore, the prevalence of NAFLD among children and adolescents is increasing, affecting approximately 3% to 10% of all children and over one-third of obese children in developed countries. The increasing prevalence of NAFLD is linked to a rise in other non-communicable diseases such as type 2 diabetes mellitus (T2DM), obesity and cardiovascular disease (CVD), which are primarily related to unhealthy lifestyles and diet. However, ageing and genetics might also play an important role, particularly in Native American and Hispanic populations.

Geographic variation in the daily energy availability per capita and the prevalence of NAFLD


  1. Younossi Z, Tacke F, Arrese M, et al. Global perspectives on non-alcoholic fatty liver disease and non-alcoholic steatohepatitis. Hepatology. 2018; Sep 4 [Epub ahead of print]
  2. EASL-EASD-EASO Clinical Practice Guidelines for the management of non-alcoholic fatty liver disease. J Hepatol. 2016;64:1388-402
  3. Chalasani N, Younossi Z, Lavine JE, et al. The diagnosis and management of nonalcoholic fatty liver disease: Practice guidance from the American Association for the Study of Liver Diseases. Hepatology. 2018;67:328-57
  4. Stefan N, Häring HU, Cusi K. Non-alcoholic fatty liver disease: causes, diagnosis, cardiometabolic consequences, and treatment strategies. Lancet Diabetes Endocrinol. 2018; Aug 30 [Epub ahead of print]
  5. Younossi ZM, Koenig AB, Abdelatif D, Fazel Y, Henry L, Wymer M. Global epidemiology of nonalcoholic fatty liver disease – Meta-analytic assessment of prevalence, incidence, and outcomes. Hepatology. 2016;64:73-84
  6. Anderson EL, Howe LD, Jones HE, Higgins JP, Lawlor DA, Fraser A. The prevalence of non-alcoholic fatty liver disease in children and adolescents: a systematic review and meta-analysis. PLoS One. 2015;10:e0140908