NASH Observatory
⏿ The PanNASH Initiative is an interactive web-based platform presenting global NASH statistics to inform NASH control and research.
B cells aggravate NASH: an innate and adaptive signalling
Authors: Barrow F, Khan S, Fredrickson G, et al.
Published in Hepatology 2021
In this study, F. Barrow et al. (University of Minnesota Medical School, Minneapolis, USA) report that NASH livers accumulate B cells with elevated pro-inflammatory cytokine secretion .....
Read MoreNAFLD: from drivers to targets
Authors: antos-Laso A, Gutiérrez-Larrañaga M, Alonso-Peña M, et al.
Published in Biomedicines 2021
In this review, A. Santos-Laso et al. (Marqués de Valdecilla University Hospital, Valdecilla Biomedical Research Institute, Santander, Spain) summarise the key aspects of NAFLD .....
Read MoreNASH: an Overview Through 200 Years of Clinical Research
Authors: Geier A, Tiniakos D, Denk H, et al.
Published in Gut 2021
Although the term 'fatty liver hepatitis' first appeared in 1962, it was in 1980 that the term 'non-alcoholic steatohepatitis' (NASH) was coined and the histopathological.....
Read MoreImmune cell-mediated features of NASH
Authors: Huby T, Gautier EL.
Published in Nat Rev Immunol 2022
In this review, T. Huby and E. L. Gautier (Sorbonne Université, Hôpital de la Pitié-Salpêtrière, Paris, France) discuss “current concepts related to the.....
Steatohepatitis: hypothesis for a pathomechanism
Authors: Abuja PM, Zatloukal K, Denk H.
Published in Int J Mol Sci 2021
In this article, P. M. Abuja et al. (Medical University of Graz, Austria) propose that steatohepatitis develops in four phases with transitions, priming triggering, adaptation....
Read MoreFatty liver through the ages: Nonalcoholic steatohepatitis
Authors: Younossi ZM, Henry L.
Published in Endocr Pract 2022
In this article, Z. M. Younossi et al. (Inova Health System, Falls Church, VA, USA) aimed to review the current literature on NAFLD and NASH as it impacts children and adults....
Read MoreParsing the role of PPARs in macrophage processes
Authors: Toobian D, Ghosh P, Katkar GD.
Published in Front Immunol 2021
In this review, D. Toobian et al. (University of California San Diego, CA, USA) underline emerging evidence of the potential roles of the PPAR subtypes in macrophage.....
AGA: a NAFLD clinical care pathway
Authors: Kanwal F, Shubrook JH, Adams LA, et al.
Published in Gastroenterology 2021
The American Gastroenterological Association assembled a multidisciplinary panel of experts to develop a Clinical Care Pathway providing explicit guidance on the.....
Read MoreAuto-aggressive CXCR6+ CD8 T cells cause liver immune pathology in NASH
Authors: Dudek, M., Pfister, D., Donakonda, S. et al.
Published in Nature 2021
Mechanistic understandings of liver damage in NASH are incomplete. In this article, using a preclinical mouse model that displays key features of human NASH, M.....
T cells: Friends and foes?
Authors: Ramadori P, Kam S, Heikenwalder M.
Published in Hepatol 2022
In this review, P. Ramadori et al. (German Center for Cancer Research (DKFZ), Heidelberg, Germany) explain the cellular crosstalk of T cells with other immune cells, regulatory.....
Identify the risk of NASH and cirrhosis: the time to screen is now
Authors: Cusi K.
Published in J Clin Endocrinol Metab 2022
Early screening and risk stratification for advanced liver fibrosis is critical in primary care and endocrinology clinics to prevent future cirrhosis in groups.....
NAFLD and structural heart, systolic and diastolic dysfunction: a meta-analysis
Authors: Yong JN, Ng CH, Lee CW, et al.
Published in Hepatol Int 2022
Several studies have documented a relationship between non-alcoholic fatty liver disease (NAFLD) and structural heart disease, particularly diastolic function. This meta-analysis by J. N. Yong et al. (Yong Loo.....
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