NASH Observatory 2023

The role of circadian clocks in the pathogenesis of NAFLD

The circadian clock controls rhythms responsible for regulating bodily functions, e.g., appropriate eating times. When this clock becomes disrupted due to factors such as irregular daily eating patterns or weekly schedules, it instead promotes lipid dysregulation, oxidative stress, and inflammation.

ByDr. S Duarte
OnDecember 15, 2022
InNASH Observatory

Hepatocellular carcinoma surveillance in NAFLD patients

Authors: Cholankeril G, El-Serag H.

Published in Seminars in liver disease 2022

Nonalcoholic fatty liver disease (NAFLD) is characterised by the presence of hepatic steatosis without significant alcohol consumption or concomitant liver disease. Patients with NAFLD-related cirrhosis are at a high risk of developing liver complications, including hepatocellular carcinoma (HCC).

MAFLD and inflammatory bowel disease: a prospective cohort study

Authors: Chen J, Dan L, Tu X et al.

Published in Hepatology International 2022

MAFLD and inflammatory bowel disease: a prospective cohort study

Coffee achieves its beneficial effects through modulation of insulin resistance in a NAFLD mouse model

Authors: Kakiyama G, Minowa K, Rodriguez-Agudo D et al.

Published in American Journal of Physiology, Gastrointestinal and Liver Physiology 2022

Coffee achieves its beneficial effects through modulation of insulin resistance in a NAFLD mouse model

B cells aggravate NASH: an innate and adaptive signalling

Authors: Barrow F, Khan S, Fredrickson G, et al.

Published in Hepatology 2021

In this study, F. Barrow et al. (University of Minnesota Medical School, Minneapolis, USA) report that NASH livers accumulate B cells with elevated pro-inflammatory cytokine secretion .....

NAFLD: from drivers to targets

Authors: antos-Laso A, Gutiérrez-Larrañaga M, Alonso-Peña M, et al.

Published in Biomedicines 2021

In this review, A. Santos-Laso et al. (Marqués de Valdecilla University Hospital, Valdecilla Biomedical Research Institute, Santander, Spain) summarise the key aspects of NAFLD .....

NASH: an Overview Through 200 Years of Clinical Research

Authors: Geier A, Tiniakos D, Denk H, et al.

Published in Gut 2021

Although the term 'fatty liver hepatitis' first appeared in 1962, it was in 1980 that the term 'non-alcoholic steatohepatitis' (NASH) was coined and the histopathological.....

Immune cell-mediated features of NASH

Authors: Huby T, Gautier EL.

Published in Nat Rev Immunol 2022

In this review, T. Huby and E. L. Gautier (Sorbonne Université, Hôpital de la Pitié-Salpêtrière, Paris, France) discuss “current concepts related to the.....

Steatohepatitis: hypothesis for a pathomechanism

Authors: Abuja PM, Zatloukal K, Denk H.

Published in Int J Mol Sci 2021

In this article, P. M. Abuja et al. (Medical University of Graz, Austria) propose that steatohepatitis develops in four phases with transitions, priming triggering, adaptation....

Fatty liver through the ages: Nonalcoholic steatohepatitis

Authors: Younossi ZM, Henry L.

Published in Endocr Pract 2022

In this article, Z. M. Younossi et al. (Inova Health System, Falls Church, VA, USA) aimed to review the current literature on NAFLD and NASH as it impacts children and adults....

Parsing the role of PPARs in macrophage processes

Authors: Toobian D, Ghosh P, Katkar GD.

Published in Front Immunol 2021

In this review, D. Toobian et al. (University of California San Diego, CA, USA) underline emerging evidence of the potential roles of the PPAR subtypes in macrophage.....

AGA: a NAFLD clinical care pathway

Authors: Kanwal F, Shubrook JH, Adams LA, et al.

Published in Gastroenterology 2021

The American Gastroenterological Association assembled a multidisciplinary panel of experts to develop a Clinical Care Pathway providing explicit guidance on the.....

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NASH Observatory

The role of circadian clocks in the pathogenesis of NAFLD

Hepatocellular carcinoma surveillance in NAFLD patients

MAFLD and inflammatory bowel disease: a prospective cohort study

Coffee achieves its beneficial effects through modulation of insulin resistance in a NAFLD mouse model

B cells aggravate NASH: an innate and adaptive signalling

NAFLD: from drivers to targets

NASH: an Overview Through 200 Years of Clinical Research

Immune cell-mediated features of NASH

Steatohepatitis: hypothesis for a pathomechanism

Fatty liver through the ages: Nonalcoholic steatohepatitis

Parsing the role of PPARs in macrophage processes

AGA: a NAFLD clinical care pathway

Burden of liver-related comorbidities in cardiovascular disease

Non-invasive assessment of cACLD & portal hypertension

Immune mechanisms behind NAFLD-associated inflammation

Global prevalences of NAFLD, NAFL and NASH in the overweight and obese population

NAFLD: a growing burden with a rising global prevalence?

Effects of mitochondrial transplant therapy on the reparation of injured skeletal muscle

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