The conventional detection of necrosis in vivo is not currently available, whereas the detection method for apoptosis has been relatively well-established.
S. Tsurusaki et al. (Research Institute, National Center for Global Health and Medicine, Tokyo, Japan) recently reported a method for the in vivo detection of necrotic cells in liver disease models. They also provide standard methods for the evaluation of lipid accumulation and fibrosis. They also show that ferroptosis, a type of apoptosis dependent on iron and characterised by the accumulation of lipid peroxides, could be involved in the pathogenesis of NASH.