Prof Sven Francque, Belgium, shares highlights from a recent paper in Nature reviews. PPARs regulate metabolism, inflammation and fibrosis, all of which determine NASH progression. Both PPARα-β/δ dual agonism as well as PPARγ agonism have shown beneficial effects on liver histology in phase IIb clinical trials for NASH.
This systematic review and meta-analysis by KM Chin et al. aimed to compare the outcomes of curative...
SA Alqahtani et al. remind us of the burden of non-alcoholic fatty liver disease (NAFLD)....
This review by KK. Bence et al. focuses on early metabolic events in the establishment of NAFL and i...
As pointed out by Gabriella Assante et al., two recent studies in the Journal of Hepatology suggest ...
Boyer-Diaz Z et al. tried to evaluate the therapeutic potential of pan-PPAR activation for the treat...
In their review, MV Chakravarthy et al. discuss key pathophysiological processes driving sarcopenia ...
This review by CM Muzica et al. aims to summarise the current literature regarding the incidence of ...
In this review, R. Tariq et al. discuss the current literature regarding the pathogenesis and clinic...
Discover the very special relationship between Non-alcoholic fatty liver disease (NAFLD) and Type 2 ...
The authors developed a Markov model to test various screening strategies and treatment for NASH in ...
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