The 5th edition of the Paris Nash Meeting is being held at the Institut Pasteur in Paris. Many of the Pannash experts are attending the conference. This is an opportunity to remember the importance of screening for Liver disease. In France, according to the cohort Constance, the prevalence of Liver disease is 18.2% of the adult French population which is 7.83 million people and 2.6% of the population with advanced disease is more than 200,000 people with a high risk of developing cirrhosis and / or liver cancer.
An understanding of the pathogenesis and natural course of NAFL and NASH is essential to develop new treatments and design clinical trials. These conditions are not static, but dynamic, and may progress or regress at variable rates in different individuals or even in the same individual at different times.
Prof Jean-François Dufour, Switzerland sheds lights on this important question.
The PanNASH initiative is led by an international, multidisciplinary expert committee
It is estimated that 25% of the global adult population is potentially affected by non-alcoholic fatty liver disease (NAFLD), with the highest prevalence in the Middle East and South America and the lowest in Africa.
Liver biopsy studies suggest that fibrosis progresses at a rate of approximately one stage per decade, suggesting that stage 2 fibrosis will progress to cirrhosis within 20 years.
NAFLD and NASH are substantial public health and economic burden.
Type 2 diabetes mellitus (T2DM) is present in about 23% of NAFLD patients and about 44% of NASH patients.(7) Moreover, NAFLD oftentimes precedes T2DM.
Yann Colardelle / Med Ed GS
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