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Attenuation coefficient liver to spleen ratio and determination of hepatic steatosis
The aim of the study was to assess ultrasound attenuation coefficient in adult liver and spleen. The authors calculated attenuation coefficient liver to spleen ratio…..
By
G. Bozet, MD
Authors
Gao J.
Published in
Clin Imaging 2022
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Bile acids profile and transition from NAFLD into NASH
Metabolomic studies suggest plasma levels of bile acids are elevated amongst subjects with NAFLD compared to healthy controls. However, it remains unclear…..
By
D. Beard
Authors
Nimer N, Choucair I, Wang Z, et al.
Published in
Metabolism 2021
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Investigating hepatocellular inflammasome activation
Inflammasome activation followed by maturation has been observed in both preclinical models and NASH patients suggesting the crucial importance of inflammasome activation in NAFLD progression……
By
G. Bozet, MD
Authors
Das D, Adak M, Chakrabarti P.
Published in
Methods Mol Biol 2022
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Pathophysiological roles of cell death in NASH
The conventional detection of necrosis in vivo is not currently available, whereas the detection method for apoptosis has been relatively well-established ….
By
D. Beard
Authors
Tsurusaki S, Kanegae K, Tanaka M.
Published in
Methods Mol Biol 2022
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Culture of mouse liver ductal organoids
3D organoid culture has become a powerful tool and model for various human diseases, including NASH. The hepatic progenitor cells can be induced to form hepatic organoids, …..
By
D. Beard
Authors
Yan J, Tai Y, Zhou H.
Published in
Methods Mol Biol 2022
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Purification and isolation of hepatic stellate cells
In an activated form, human hepatic stellate cells are the drivers of fibrosis following chronic liver injury. In NASH specifically, activated human hepatic stellate cells are drivers of induction and progression of fibrogenesis. …..
By
By G. Bozet, MD
Authors
Lele S, Lee SD, Sarkar D, et al.
Published in
Methods Mol Biol 2022
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Study of hepatocytes: adenovirus for basic medical research
Deciphering the molecular mechanisms underlying the pathogenesis of NASH requires loss- or gain-of-function experimental approaches. Adenovirus is a fast, effective, and versatile tool that allows transient knockdown, …..
By
D. Beard
Authors
Liu Y, Xu S, Liu Y, et al.
Published in
Methods Mol Biol 2022
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A liver targeted gene delivery system
NASH is characterized by multiple underlying genetic mutations, with no approved cure to date. Gene therapies that target those genetic mutations may play a major role in treating this disease, once delivered specifically to the hepatocytes. …..
By
G. Bozet, MD
Authors
Ebeid K, Geary SM, Salem AK.
Published in
Methods Mol Biol 2022
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MAFLD/NAFLD biopsy-free scoring systems
The current clinical practice is urged to incorporate biopsy-free scoring systems that demonstrate adequate performance metrics for the accurate detection of patients with MAFLD and underlying …..
By
G. Bozet, MD
Authors:
Segura-Azuara N, Varela-Chinchilla CD, Trinidad-Calderón PA.
Published in:
Front Med (Lausanne) 2021
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NASH: Bile acid profiling
Bile acids synthesis and metabolism have been impaired in NASH patients because of liver injury, inflammation or obstruction of bile ducts. Changes in bile acids composition might contribute to NASH …..
By
D. Beard
Authors:
Kong B, Rizzolo D, Taylor RE, et al
Published in:
Methods Mol Biol 2022
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NAFLD signature in adipose tissue
Development and severity of NAFLD have been linked to obesity and white adipose tissue dysfunction plays a key role in this relation. Ó. Osorio-Conles et al. ….
By
D. Beard
Authors:
Osorio-Conles Ó, Vega-Beyhart A, Ibarzabal A, et al.
Published in:
Int J Mol Sci 2021
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NAFLD-MAFLD: is there a consensus-on-consensus methodology?
The so far well-received new name and redefinition of fatty liver disease have generated debates. The most common argument is that …..
By
G. Bozet, MD
Authors
Fouad Y, Dufour JF, Zheng MH, et al.
Published in
Liver Int 2022
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Heart rate variability and risk of NAFLD
I. Y. CHoi et al. (Total Healthcare Centre, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, South Korea) investigated the association …..
By
D. Beard
Authors
Choi IY, Chang Y, Kang G, et al.
Published in
Sci Rep 2022
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Poor Sleep Quality and risk of NAFLD
The impact of changes in sleep duration and sleep quality over time on the risk of NAFLD is not known. In a cohort study included 86,530 Korean adults…..
By
G. Bozet, MD
Authors:
Um YJ, Chang Y, Jung HS, et al.
Published in:
J Pers Med 2022
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Cellular Senescence and NAFLD
In this review, C. Engelmann C and F. Tacke (Campus Virchow-Klinikum and Campus Charité Mitte, Charité-Universitätsmedizin Berlin, Germany) critically discuss the currently …..
Reviewed by
G. Bozet, MD
Authors
Engelmann C, Tacke F.
Published in
Int J Mol Sci 2022
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Colonic Diverticulosis and NAFLD
This retrospective study aimed to evaluate a possible connection between NAFLD, colonic diverticulosis, and metabolic syndrome.For the authors,……
Reviewed by
D. Beard
Authors
Pantic I, Lugonja S, Rajovic N, et al.
Published in
Medicina (Kaunas) 2021
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Non-alcoholic fatty liver disease in irritable bowel syndrome: More than a coincidence?
Recently, there has been interest in the apparent co-incidence of NAFLD in patients with IBS mainly driven by improved understanding of their shared risk factors and pathophysiology H. Purssell et al. (Manchester University NHS Foundation Trust, UK)……
Reviewed by
G. Bozet, MD
Authors
Purssell H, Whorwell PJ, Athwal VS, et al.
Published in
World J Hepatol 2021
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Non-invasive risk stratification in NAFLD/NASH patients for screening esophagogastroduodenoscopy
J. Romano et al. (Medical University of South Carolina, Charleston, USA) evaluated whether these non-invasive markers and/or any other clinical parameters may be used to identify patients with liver cirrhosis who are likely to have large….
Reviewed by
D. Beard
Authors
J, Abdelfattah T, Manka PP, et al.
Published in
Clin Exp Gastroenterol 2022
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Chronopharmacology, or timing of drug administration in NASH
Liver homeostasis is strongly influenced by the circadian clock. Disruption of the clock has been heavily implicated in the pathogenesis of NAFLD and NASH. There has been little consideration of the application of chronopharmacology in NASH, a strategy whereby…..
Reviewed by
G. Bozet, MD
Authors
Marjot T, Ray DW, Tomlinson JW.
Published in
J Hepatol 2022
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A nutritional approach increase vegetable consumption in some NAFLD patients
The aim of this study was to investigate whether a nutritional intervention motivating increased vegetable consumption would be an effective treatment and diet therapy for patients with non-alcoholic fatty liver disease. During the 6-month intervention …..
Reviewed by
D. Beard
Authors
Sugiyama H, Kobayashi Y, Sumida Y, et al.
Published in
J Clin Biochem Nutr 2022
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Obese and overweight children: screening for early diagnosis of NAFLD is essential
NAFLD is increasingly recognised in obese and overweight children. In this cross-sectional study, S. Thiagarajan et al. (Indira Gandhi Medical College and Research Institute, India) aimed to assess the prevalence of NAFLD in this population and to identify the associated….
Reviewed by
G. Bozet, MD
Authors
Thiagarajan S, Shrinuvasan S, Arun Babu T.
Published in
Indian J Gastroenterol 2022
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NAFLD/NASH: a novel pro-carcinogenic contribution for oncostatin M
Oncostatin M is a pleiotropic cytokine of the interleukin (IL)-6 family that contributes to the progression of chronic liver disease. G. Di Maira et al. (University of Firenze, Italy) aimed to investigate the role of oncostatin M in the development and progression of hepatocellular…..
Reviewed by
D. Beard
Authors
Di Maira G, Foglia B, Napione L, et al.
Published in
J Pathol 2022
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Weight-loss alone may not be sufficient to reverse advanced fibrosis
R. Pais et al. (Hôpital Pitié-Salpêtrière, Paris, France) describe the histological outcome in patients with advanced NASH and its relationship with weight loss and metabolic improvement after bariatric surgery. For the authors, “while bariatric surgery successfully…
Reviewed by
G. Bozet, MD
Authors
Pais R, Aron-Wisnewsky J, Bedossa P, et al.
Published in
Hepatology 2022
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NAFLD and type 2 diabetes, a review
This review by C. H. Lee et al. (University of Hong Kong, Hong Kong) aims to provide a summary of the latest evidence that support NAFLD as an emerging diabetic complication of increasing importance, and to present the current recommendations…
Reviewed by
D. Beard
Authors
Lee CH, Lui D, Lam K.
Published in
J Diabetes Investig 2022
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Advanced NAFLD: measuring microRNA in a blood sample
MicroRNA levels in blood may change in liver disease including NAFLD. K. Johnson et al. (Newcastle University, UK) carried out microRNA sequencing in a group of 183 patients with NAFLD. One particular microRNA miR-193a-5p consistently increased…
Reviewed by
G. Bozet, MD
Authors
Johnson K, Leary PJ, Govaere O, et al.
Published in
JHEP Rep 2022
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MAFLD might cause structural damage to brain cells
MAFLD might be considered as a multisystem disease that affects not only the liver but involves wider implications, relating to several organs and systems, the brain included.The present study by S. Nucera et al. (University Magna Graecia of Catanzaro, Italy) …
Reviewed by
D. Beard
Authors
Nucera S, Ruga S, Cardamone A, et al.
Published in
Sci Rep 2022
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NAFLD and MAFLD as emerging causes of hepatocellular carcinoma
Hepatocellular carcinoma is the most common type of liver cancer, increasingly arising in patients with NAFLD or MAFLD. S. Myers et al. (University of Geneva, Switzerland) assessed all patients with hepatocellular carcinoma between 1990 and 2014 in the canton of Geneva….
Reviewed by
G. Bozet, MD
Authors
Myers S, Neyroud-Caspar I, Spahr L, et al.
Published in
JHEP Reports 2021
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Liver transplant recipients: NASH is frequent
To investigate incidence and predictors of NAFLD and NASH by employing noninvasive testing in liver transplant recipients (i.e. controlled attenuation parameter and cytokeratin 18), A. Alhinai et al. (McGill University, Montreal, Canada) prospectively…
Reviewed by
D. Beard
Authors
Alhinai A, Qayyum-Khan A, Zhang X, et al.
Published in
World J Hepatol 2021
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Non-obese MAFLD is associated with colorectal adenoma
Colorectal adenoma is linked to metabolic dysfunction. S. Fukunaga et al. (Kurume University School of Medicine, Japan) aimed to investigate the impact of MAFLD on the prevalence of colorectal adenoma by comparing it to NAFLD in health check-up examinees in a multicenter retrospective study….
Reviewed by
G. Bozet, MD
Authors
Fukunaga S, Nakano D, Kawaguchi T, et al.
Published in
International Journal of Molecular Sciences 2021
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NASH limits anti-tumour surveillance in immunotherapy-treated HCC
According to this article by D. Pfister et al. (German Cancer Research Center, Germany), the response to immunotherapy is better in patients with virus-induced HCC than in patients with non-viral HCC (that is, NASH). This might be due to the amount or quality of viral antigens….
Reviewed by
D. Beard
Authors
Pfister D, Núñez NG, Pinyol R, et al.
Published in
Nature 2021
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NASH: bariatric surgery and major adverse liver and cardiovascular outcomes
In this retrospective cohort study of 1158 patients with biopsy-proven fibrotic NASH without cirrhosis, bariatric surgery was significantly associated with a lower risk of major adverse liver outcomes and major adverse cardiovascular events. For the authors, in this study….
Reviewed by
G. Bozet, MD
Authors
Aminian A, Al-Kurd A, Wilson R, et al.
Published in
JAMA 2021
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Pathogenesis of NASH and dynamic changes in liver macrophages
Macrophage-mediated inflammation is critical in the pathogenesis of NASH. T-cell immunoglobulin domain and mucin domain-4 (TIM-4) is selectively expressed on antigen-presenting cells and modulates various immune responses. However, the role of TIM-4 expressed by Kupffer cells in liver fibrosis remains unclear….
Reviewed by
D. Beard
Authors
Daemen S, Gainullina A, Kalugotla G, et al.
Published in
Cell reports 2021
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