Epidemiology Articles

Gain free access to the latest articles on the NASH and NAFLD epidemic by a global expert community. ⌨

NASH Epidemic: a call to action

NAFLD and NASH are common conditions with a rising burden. As pointed out by F. Kanwal et al. (Baylor College of Medicine, and Michael E. DeBakey Veterans Affairs Medical Center, Houston,USA), “yet there are significant management gaps between clinical guidelines and practice in patients with NAFLD and NASH. Further, there is no single...

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Genetic and epigenetic factors determining NAFLD risk

Predicting the individual risk of NAFLD and determining the probability of disease progression is the basis for further developing prevention and treatment strategies. This requires knowledge of the genetic and epigenetic modifiers of NAFLD for genotype-guided risk stratification...

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Children with suspected NAFLD: negative for other causes of liver disease

T. Yodoshi et al. (Cincinnati Children's Hospital Medical Center, USA) aimed to determine the prevalence of alternative causes of liver disease in a multicenter, retrospective cohort of 900 children with overweight and obesity patients aged ≤18 years with overweight and obesity, referred for suspected NAFLD...
Read MoreChildren with suspected NAFLD: negative for other causes of liver disease

Treatment of 3 major risk factors and fibrosis stage regression

Currently, no established hierarchy exists for the influence of metabolic risk factors on NAFLD progression. In this retrospective cohort study, V. J. H Yao et al. (CUNY School of Medicine/Sophie Davis Biomedical Education Program, New York, USA) investigated and ranked the independent and combined effects of three major risk...
Read MoreTreatment of 3 major risk factors and fibrosis stage regression

Japan: NAFLD may affect half of the population by 2040

In this systematic review and meta-analytic approach combining study level with individual patient-level data, T. Ito et al. (Nagoya University Graduate School of Medicine, Japan) aimed to investigate the epidemiology of NAFLD in Japan with a focus on lean NAFLD. The overall NAFLD prevalence was 25.5%, and increased over time...
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Liver transplantation indications in Saudi Arabia: NASH has eclipsed HCV

Our understanding of fatty liver syndromes and their relationship with the metabolic syndrome has improved over recent decades and, paralleling this, we are now at the dawn of the NAFLD (non-alcoholic fatty liver disease) to MAFLD (metabolic-associated fatty liver disease) transition...
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Prevalence of NAFLD and MAFLD in the US population

S. Ciardullo et G. Perseghin (Policlinico di Monza, and University of Milano Bicocca, Italy) performed a cross-sectional study of adults recruited in the 2017-2018 NHANES Survey, a representative sample of the general US population, in order to determine the prevalence of NAFLD, MAFLD and associated advanced fibrosis in the US population...
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The global burden of cirrhosis: the role of NAFLD

The World Health Organization’s metric of public health burden is the disability-adjusted life-year (DALY), the sum of years of life lost due to premature death and years of life lived with disability. Cirrhosis was responsible for 26.8% fewer DALYs in 2019 than in 1990, which is positive...
Read MoreThe global burden of cirrhosis: the role of NAFLD