Published in Expert Rev Gastroenterol Hepatol 2021
Recently, a consensus recommended 'metabolic (dysfunction) associated fatty liver disease' as a more appropriate name to describe fatty liver disease associated with metabolic dysfunction (MAFLD). This single-letter change in the NAFLD acronym suggests that the old acronyms should be abandoned...
S. Ciardullo et G. Perseghin (Policlinico di Monza, and University of Milano Bicocca, Italy) performed a cross-sectional study of adults recruited in the 2017-2018 NHANES Survey, a representative sample of the general US population, in order to determine the prevalence of NAFLD, MAFLD and associated advanced fibrosis in the US population...
Our understanding of fatty liver syndromes and their relationship with the metabolic syndrome has improved over recent decades and, paralleling this, we are now at the dawn of the NAFLD (non-alcoholic fatty liver disease) to MAFLD (metabolic-associated fatty liver disease) transition. The pitfalls of NAFLD diagnosis...
Polarising opinions and major debate have recently arisen in hepatology on the nomenclature and diagnostic criteria for fatty liver disease associated with metabolic dysfunction.The aim of this viewpoint by Y. Fouad et al. (Faculty of Medicine, Minia University, Egypt) is to suggest...
Authors: Younossi ZM, Rinella ME, Sanyal AJ, et al.
Published in Hepatology 2021
Despite the substantial gains in our understanding of NAFLD/NASH over the past 2 decades, there has been some dissatisfaction with the terminology “non-alcoholic” which overemphasises “alcohol” and underemphasises the predisposing metabolic risk factors.
The term MAFLD is still suboptimal, leaving a great deal of ambiguity...
A systematic literature review to identify recent epidemiological, biomarker, genetic and clinical evidence that expands our understanding of NAFLD as a metabolic disorder was performed by B. Cariou et al. (Inserm, CNRS, France). It appears that here is a growing body of evidence on the links between NAFLD/NASH pathogenesis and mechanisms of metabolic dysfunction...
Globally, liver biopsy remains the reference standard for staging NAFLD severity. To diagnose NAFLD and quantify liver fat, MRI proton density fat fraction may be more informative than liver biopsy. In this review, V. Ajmera and R. Loomba (University of California, USA) critically examine the use...
A significant subset of patients with NAFLD are lean, but the underlying pathophysiology in this group is poorly understood. F. Chen et al. (Westmead Hospital, University of Sydney, Australia) investigated the pathogenesis of lean NAFLD in a cohort of Caucasian patients with biopsy proven disease, and in experimental murine models...
The exclusion of other chronic liver diseases including “excess” alcohol intake are usually necessary to establish a diagnosis of metabolic dysfunction-associated fatty liver disease (MAFLD). However, “positive criteria” to diagnose the disease are required. A panel of international experts from 22 countries...
SUBSCRIBE TO OUR MONTHLY NEWSLETTER TO GET THE LATEST UPDATES
Strictly necessary or essential cookies are absolutely necessary for the proper functioning of the website. This category only includes cookies that guarantee the basic functionality and security features of the website. Without these cookies, it would not be possible to access the services or the website and therefore this category cannot be disabled. These cookies do not store any personal information.
This cookie is associated withAmazon Web Services Elastic Load Balancing functionality. It is used to honor sticky sessions and enable target group stickiness. When the load balancer first routes a request to a weighted target group, the cookie is generated and included in subsequent requests to the load balancer. It is used to route requests to the target group specified in the cookie. Specifically, the AWSALBTGCORS cookie is used with CORS (cross-origin resource sharing) requests that require the SameSite attribute to enable stickiness. It includes all the same information as the AWSALBTG cookie, plus the set SameSite attribute.
This cookie is set by GDPR Cookie Consent plugin. The purpose of this cookie is to store whether or not the user has given consent for cookie usage. It does not store any personal data.
This cookie is set by GDPR Cookie Consent plugin. It records the default button state of the corresponding category & the status of California Consumer Privacy Act (CCPA). It works only in coordination with the primary cookie, viewed_cookie_policy.
Functional cookies help to perform certain functionalities like sharing the content of the website on social media platforms, collect feedbacks, and other third-party features.
ppwp_wp_session is a cookie is native to PHP applications. The cookie is used to store and identify a users' unique session ID for the purpose of managing the user's session on the website. The cookie is a session cookie and is deleted when all browser windows are closed.
The services in this section allow the data controller to monitor and analyze traffic data and are used to track user behaviour.
The Google Analytics GA4 services used for our website allows us to record visitors and identify how we use the site. It is a statistical tool that allows us to improve our website taking into account the needs of visitors.
The data generated by these cookies concern:
website's use, as the pages visited;
your IP address to determine the connection city.
This data is immediately anonymized after localization
This cookie is installed by Google Analytics GA4. The cookie is used to calculate the data of visitors, sessions, camapigns and keep track of the use of the site for the site analysis report. Cookies store information anonymously and assign a randomly generated number to identify unique visitors.
This cookie is installed by Google Analytics GA4. The cookie is used to distinguish users. Cookies store information anonymously and assign a randomly generated number to identify unique visitors.