Epidemiology Articles

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NAFLD burden in Asia and MENA regions

Authors: Golabi P, Paik JM, AlQahtani S, et al.
Published in J Hepatol 2021
P. Golabi et al. assessed the burden of liver complications (cirrhosis and liver cancer) related to NAFLD between 2009-2019 in Asia and MENA (Middle East and Northern Africa) regions, using Global Burden of Disease data to assess incidence, mortality, and disability-adjusted-life-years (DALYs)...
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Obesity and liver cancer in Japan

Authors: Nishikawa H, Fukunishi S, Asai A, et al.
Published in Anticancer Res 2021
It is estimated that there are more than 10 million NAFLD patients in Japan. 10-20% of NASH patients will progress to liver cirrhosis and 2-3% of them will develop hepatocellular carcinoma per year. In their review, H. Nishikawa et al. (Osaka Medical and Pharmaceutical University, Takatsuki, and Hyogo College of Medicine, Japan) comprehensively...
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Increasing prevalence of NAFLD/NASH among children, adolescents, and young adults

Authors: Zhang X, Wu M, Liu Z, et al.
Published in BMJ Open 2021
X. Zhang et al. (Fudan University, Shanghai, China) collected, from the Global Burden of Disease database, annual cases, and prevalence of NAFLD/NASH from 1990 to 2017, by sex, region and country. This study shows that both the prevalence and number of cases of NAFLD/NASH have...
Read MoreIncreasing prevalence of NAFLD/NASH among children, adolescents, and young adults

Burden of NAFLD in Canada

Authors: Swain MG, Ramji A, Patel K, et al.
Published in CMAJ Open 2020
M. G. Swain et al. (University of Calgary, Canada) used a Markov model to forecast the burden of disease of NAFLD and NASH among Canadians with NAFLD from 2019 to 2030. The model projected that the number of NAFLD cases would increase by 20% between 2019 and 2030. Increasing rates of obesity ...
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NAFLD burden in Australia, 2019-2030

Authors: Adams LA, Roberts SK, Strasser SI, et al.
Published in J Gastroenterol Hepatol 2020
The burden of NAFLD/NASH manifests in increasing levels of advanced liver disease and primary liver cancer in Australia. L. A. Adams et al. (The University of Western Australia, Perth, Australia) used a Markov model to forecast NAFLD burden in Australia through 2030. Prevalent NAFLD cases were projected to increase 25% from the current...
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Epidemiology: NAFLD from 1999 to 2018 in China

Authors: Zhou J, Zhou F, Wang W, et al.
Published in Hepatology 2020
For J. Zhou et al. (Wuhan University, China), NAFLD has become the most prevalent liver disorder in China but has not received sufficient attention. NAFLD-related advanced liver disease and its mortality along with its overall disease burden are expected to increase substantially. In their meta-analysis, the authors summarise eight...
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NAFLD progression rates: a real-world analysis

Authors: Loomba R, Wong R, Fraysse J, et al.
Published in Aliment Pharmacol Ther 2020
The aim of this study by R. Loomba et al. (NAFLD Research Center, University of California, San Diego, USA) was to evaluate the impact of disease severity, demographics and comorbidities on risk of mortality and time to progression in a large, real-world cohort of diagnosed NAFLD patients...
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Adult US population: NAFLD prevalence 38%, NASH 14%

Authors: Harrison SA, Gawrieh S, Roberts K, et al.
Published in J Hepatol 2021
S. A. Harrison et al. (Radcliffe Department of Medicine, University of Oxford, UK) prospectively assessed the prevalence and severity of NAFLD/NASH in a cohort of asymptomatic middle-aged Americans attending a colonoscopy class at a gastroenterology clinic. Screening for NAFLD was performed using magnetic resonance...
Read MoreAdult US population: NAFLD prevalence 38%, NASH 14%

Prevalence trends in NAFLD according to the Global Burden of Disease study

Authors: Ge X, Zheng L, Wang M, et al.
Published in BMJ Open 2020
This study comprehensively investigated temporal trends in NAFLD prevalence at the global, regional, and national levels. The study included 21 regions and 195 countries or territories. The authors assessed secular trends in NAFLD risk factors, according...
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Changing trends of liver transplantation and mortality from NAFLD

Authors: Majumdar A, Tsochatzis EA
Published in Metabolism 2020
This review by A. Majumdar (Australian National Liver Transplant Unit, Royal Prince Alfred Hospital, Sydney, and University of Sydney, Australia) and E. Tsochatzis (UCL Institute for Liver and Digestive Health, Royal Free Hospital and UCL, London, and Sheila Sherlock Liver Centre, Royal Free Hospital, London, UK) outlines the current epidemiology, natural history...
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Prevalence of steatosis and fibrosis in young adults in the UK

Authors: Abeysekera KWM, Fernandes GS, Hammerton G, et al.
Published in Lancet Gastroenterol Hepatol 2020
The study by KWM Abeysekera et al. (Population Health Sciences, Bristol Medical School, University of Bristol, and University Hospitals Bristol NHS Foundation Trust, Bristol, UK) is the first to determine the prevalence of NAFLD in young adults with use of transient electrography, in an age group in which NAFLD burden is poorly characterized...
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NALFD in the Asia-Pacific region

Authors: Sarin SK, Kumar M, Eslam M, et al.
Published in Lancet Gastroenterol Hepatol 2020
Data on NALFD epidemiology in the Asia-Pacific region indicate a rapid increase in the disease’s burden over the past three decades, which is supported by a systematic review and meta-analysis that assessed the prevalence, incidence, and outcomes of NAFLD in Asia. The analysis estimated that the overall prevalence of NAFLD...
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