Management Articles

Bariatric surgery is an efficient method 🕙 to achieve significant weight loss for NASH/NAFLD, learn more from our management articles.

NAFLD in the elderly

Authors: Alqahtani SA, Schattenberg JM.
Published in Clin Interv Aging 2021
The diagnosis and management strategies of NAFLD in older adults are sometimes challenging, and certain age-specific factors have to be taken into account. In this review, S. A. Alqahtani (King Faisal Specialist Hospital & Research Center, Saudi Arabia and Johns...
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NASH Epidemic: a call to action

Authors: Kanwal F, Shubrook JH, Younossi Z, et al.
Published in Gastroenterology 2021
NAFLD and NASH are common conditions with a rising burden. As pointed out by F. Kanwal et al. (Baylor College of Medicine, and Michael E. DeBakey Veterans Affairs Medical Center, Houston,USA), “yet there are significant management gaps between clinical guidelines and practice in patients with NAFLD and NASH. Further, there is no single...
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Phytomedicines in experimental models of NAFLD

Authors: Ore A, Akinloye OA.
Published in Medicina (Kaunas) 2021
This systematic review aims to investigate the potential multi-targeting effects of plant-derived extracts in experimental models of NAFLD. The authors, A. Ore et al., (Ajayi Crowther University, Oyo, and Federal University of Agriculture, Abeokuta, Nigeria) identified 9 articles fulfilling their inclusion criteria...
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Liver organoid cultures and development of new therapeutic agents

Authors: Yamamoto H, Usui T, Sasaki K.
Published in Nihon Yakurigaku Zasshi 2021
In this review in Japanese, H. Yamamoto et al. (Tokyo University of Agriculture and Technology, Japan) outline the current issues in the diagnosis and treatment of NASH and introduce their research for the discovery of early diagnostic markers and the development of new therapeutic agents using liver organoid cultures derived from mouse models of NASH...
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Physical activity, cardiorespiratory fitness and NAFLD

Authors: Kerr CJ, Waterworth SP, Brodie D, et al.
Published in J Gastroenterol Hepatol 2021
High levels of physical activity and cardiorespiratory fitness may protect against NAFLD. C. J. Kerr et al. (University of Essex, UK) investigated whether different physical activity intensities, and cardiorespiratory fitness, were independent predictors of non-alcoholic fatty liver disease...
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Meta-analysis: NAFLD and melatonin supplementation

Authors: Mansoori A, Salimi Z, Hosseini SA, et al.
Published in Complement Ther Med 2020
This meta-analysis was conducted to evaluate the effect of melatonin on liver indices in patients with NAFLD. The results showed that melatonin had a significant effect on aspartate aminoteransferase , alkaline phosphatase, and gamma-glutamyltransferase, but no significant effect on alanine aminotransferase...
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Emerging drugs targeting specific points in NASH pathogenesis

Authors: Stojsavljevic-Shapeski S, Duvnjak M, Virovic-Jukic L,
et al.
Published in J Clin Transl Hepatol 2021
Extensive research and revelation in the field of pathogenesis of NASH has offered new possibilities of treatment and emerging new drugs that are being tested currently in numerous preclinical and clinical trials. These drugs target almost all steps in the pathogenesis of NASH...
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The Significance of the Mediterranean Diet in the Management of Non-Alcoholic Fatty Liver Disease: A Systematic Review

Authors: Gosal H, Kaur H, Chakwop Ngassa H, et al.
Published in Cureus 2021
In this systematic review, H. Gosal et al. (California Institute of Behavioral Neurosciences & Psychology, USA & Government Medical College, Amritsar, India) reviewed the effectiveness of the Mediterranean diet on NAFLD and its efficacy in disease management...
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Eight recommendations to improve NAFLD care models

Authors: Lazarus JV, Anstee QM, Hagstrom H, et al.
Published in Nat Rev Gastroenterol Hepatol 2021
Little attention has been given to the design and implementation of efficient and effective models of care for patients with NAFLD. In many health-care settings, no formal pathways exist, or are often not standardised according to good practices...
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Pharmacotherapy in NAFLD/NASH

Authors: Attia SL, Softic S, Mouzaki M.
Published in Clin Transl Sci 2021
This review by SL Attia et al. (University of Kentucky College of Medicine, USA) summarises emerging pharmacotherapies for the treatment of adult and paediatric NAFLD. Investigated pharmacotherapies include lanifibranor (IVA337), an indole sulfonamide PPAR agonist that activates....
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European NAFLD guidelines: limitations when applied to T2D patients

Authors: Besutti G, Bonilauri L, Manicardi E, et al.
Published in Diabetes Res Clin Pract 2021
G. Besutti et al. aimed to evaluate the feasibility and efficiency of a guidelines-compliant NAFLD assessment algorithm in patients with newly diagnosed type 2 diabetes. Consecutive patients newly diagnosed with T2D without coexisting liver disease or excessive alcohol consumption were enrolled. They were stratified...
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