The role of H. pylori infection in the development of NAFLD remains controversial. This retrospective study was conducted on 71,633 participants. .....
Authors: Mikolasevic I, Domislovic V, Krznaric-Zrnic I, et al.
Published in Medicina (Kaunas) 2022
This first study on Croatian patients with NAFLD was conducted to evaluate the diagnostic performance of various biomarkers for steatosis, fibrosis, and inflammation in comparison to a liver biopsy.....
The aim of the study was to assess ultrasound attenuation coefficient in adult liver and spleen. The authors calculated attenuation coefficient liver to spleen ratio.....
Metabolomic studies suggest plasma levels of bile acids are elevated amongst subjects with NAFLD compared to healthy controls. However, it remains unclear.....
Inflammasome activation followed by maturation has been observed in both preclinical models and NASH patients suggesting the crucial importance of inflammasome activation in NAFLD progression......
The conventional detection of necrosis in vivo is not currently available, whereas the detection method for apoptosis has been relatively well-established ....
3D organoid culture has become a powerful tool and model for various human diseases, including NASH. The hepatic progenitor cells can be induced to form hepatic organoids, .....
In an activated form, human hepatic stellate cells are the drivers of fibrosis following chronic liver injury. In NASH specifically, activated human hepatic stellate cells are drivers of induction and progression of fibrogenesis. .....
Prof. Stephen Harrison (USA) discusses state of the art management of non-alcoholic steatohepatitis (NASH) in 2022. He focuses on the benefits of lifestyle recommendations, including nutrition and exercise. He shows that weight loss is associated with NASH resolution and fibrosis regression over time following bariatric surgery in patients with severe obesity and NASH.
This video presents a comprehensive review of non-alcoholic fatty liver disease (NAFLD) & non-alcoholic steatohepatitis (NASH), delivered by international experts with a multidisciplinary approach: Dr. Maarten Tushuizen, Prof. A.G (Onno) Holleboom, and Prof. Sven Francque, along with chair, Prof. Stefan Anker. They review the epidemiology of NAFLD / NASH, its increasing prevalence rates, and discuss current best practices to improve patient outcomes.
Deciphering the molecular mechanisms underlying the pathogenesis of NASH requires loss- or gain-of-function experimental approaches. Adenovirus is a fast, effective, and versatile tool that allows transient knockdown, .....
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