Commented Articles

PanNASH covers commented articles ans publications to acquire sufficient information, understanding, and skills to cope with NASH/NAFLD healthcare demands.

Review: NAFLD, driver of chronic kidney disease

The relationship between NAFLD and chronic kidney disease has attracted much attention recently. NAFLD and chronic kidney disease may share common pathogenic mechanisms, such as insulin resistance, type 2 diabetes mellitus, hyperlipidemia and obesity, and thus may potentially share same therapeutic targets. Growing evidence suggests...
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Children with suspected NAFLD: negative for other causes of liver disease

T. Yodoshi et al. (Cincinnati Children's Hospital Medical Center, USA) aimed to determine the prevalence of alternative causes of liver disease in a multicenter, retrospective cohort of 900 children with overweight and obesity patients aged ≤18 years with overweight and obesity, referred for suspected NAFLD...
Read MoreChildren with suspected NAFLD: negative for other causes of liver disease

The Significance of the Mediterranean Diet in the Management of Non-Alcoholic Fatty Liver Disease: A Systematic Review

In this systematic review, H. Gosal et al. (California Institute of Behavioral Neurosciences & Psychology, USA & Government Medical College, Amritsar, India) reviewed the effectiveness of the Mediterranean diet on NAFLD and its efficacy in disease management...
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Treatment of 3 major risk factors and fibrosis stage regression

Currently, no established hierarchy exists for the influence of metabolic risk factors on NAFLD progression. In this retrospective cohort study, V. J. H Yao et al. (CUNY School of Medicine/Sophie Davis Biomedical Education Program, New York, USA) investigated and ranked the independent and combined effects of three major risk...
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Japan: NAFLD may affect half of the population by 2040

In this systematic review and meta-analytic approach combining study level with individual patient-level data, T. Ito et al. (Nagoya University Graduate School of Medicine, Japan) aimed to investigate the epidemiology of NAFLD in Japan with a focus on lean NAFLD. The overall NAFLD prevalence was 25.5%, and increased over time...
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Dynamic changes in liver macrophage subsets during NASH

Macrophage-mediated inflammation is critical in the pathogenesis of NASH. However, the underlying mechanisms remain unclear. In this study, S. Daemen et al. (Washington University School of Medicine, St. Louis, MI, USA) evaluated intra-hepatic macrophage composition in a mouse model of obesity with NAFLD and in a model of NASH...
Read MoreDynamic changes in liver macrophage subsets during NASH

MAFLD or NAFLD: reasons and relevance of a single-letter change

Recently, a consensus recommended 'metabolic (dysfunction) associated fatty liver disease' as a more appropriate name to describe fatty liver disease associated with metabolic dysfunction (MAFLD). This single-letter change in the NAFLD acronym suggests that the old acronyms should be abandoned...

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Liver transplantation indications in Saudi Arabia: NASH has eclipsed HCV

Our understanding of fatty liver syndromes and their relationship with the metabolic syndrome has improved over recent decades and, paralleling this, we are now at the dawn of the NAFLD (non-alcoholic fatty liver disease) to MAFLD (metabolic-associated fatty liver disease) transition...
Read MoreLiver transplantation indications in Saudi Arabia: NASH has eclipsed HCV

Prevalence of NAFLD and MAFLD in the US population

S. Ciardullo et G. Perseghin (Policlinico di Monza, and University of Milano Bicocca, Italy) performed a cross-sectional study of adults recruited in the 2017-2018 NHANES Survey, a representative sample of the general US population, in order to determine the prevalence of NAFLD, MAFLD and associated advanced fibrosis in the US population...
Read MorePrevalence of NAFLD and MAFLD in the US population