Commentary
The relationship between NAFLD and chronic kidney disease has attracted much attention recently. NAFLD and chronic kidney disease may share common pathogenic mechanisms, such as insulin resistance, type 2 diabetes mellitus, hyperlipidemia and obesity, and thus may potentially share same therapeutic targets. Growing evidence suggests that patients with NAFLD have a higher risk of chronic kidney disease than non-NAFLD population, regardless of the presence of potential confounding diseases such as obesity, hypertension and type 2 diabetes.
What is the evidence for an association and causal link between NAFLD and chronic kidney disease? What are the underlying mechanisms by which NAFLD may increase the risk of developing chronic kidney disease? This narrative review by CD Byrne and G. Targher provides an overview of the literature.
