NASH Observatory

⏿ The PanNASH Initiative is an interactive web-based platform presenting global NASH statistics to inform NASH control and research.

Imaging biomarkers in NAFLD: Could they avoid liver biopsy

Prof.-Manuel-Romero-Gomez

There is a need for new biomarkers that allow the detection and quantification of liver diseases supported on the measurement of fat, iron, fibrosis, inflammation. Dr Romero-Gomez presents a state-of-the-art video on imaging biomarkers with the pros and cons for each technology. For daily practice, he also suggests a diagnosis algorithm

Read MoreImaging biomarkers in NAFLD: Could they avoid liver biopsy

NAFLD and risk factors: accuracy and limitations of the ICD-10-Australian Modification

Understanding the limitations of International Classification of Diseases (ICD) codes is important to improve the reliability of health system databases for epidemiological studies and health services research. KL Hayward et al. conducted a retrospective audit to explore the accuracy and limitations of the ICD-10-Australian Modification...
Read MoreNAFLD and risk factors: accuracy and limitations of the ICD-10-Australian Modification

Awareness of suffering of advanced liver disease in patients with T2D is remarkably low

The aim of the present population-based cross-sectional study is to estimate the awareness of liver disease among patients with T2D and whether it differs according to the degree of liver fibrosis estimated by transient elastography. The authors included all patients with T2D that participated in the 2017-2018 cycle of the NHAHES Survey and underwent...
Read MoreAwareness of suffering of advanced liver disease in patients with T2D is remarkably low

NAFLD burden in Australia, 2019-2030

The burden of NAFLD/NASH manifests in increasing levels of advanced liver disease and primary liver cancer in Australia. L. A. Adams et al. (The University of Western Australia, Perth, Australia) used a Markov model to forecast NAFLD burden in Australia through 2030. Prevalent NAFLD cases were projected to increase 25% from the current...
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Inflammation in NASH and the transition to HCC: an update on scientific breakthroughs by Dr Peiseler and Prof Tacke, Germany

Prof. F. Tacke

As the International NASH day draws more attention to NASH, it’s important to remember that hepatocarcinoma (HCC) is the 2nd most common cause of cancer related death. Dr M. Peiseler and Dr F. Tacke, Charité hospital, Berlin, Germany present the latest scientific information about NASH as a systemic disease, represented by a common inflammatory ‘NAFLD phenotype’ of myeloid cells in liver and bone marrow. They highlight the role of inflammation and its multiple markers.

Read MoreInflammation in NASH and the transition to HCC: an update on scientific breakthroughs by Dr Peiseler and Prof Tacke, Germany

NAFLD and severe fibrosis are associated with to a high CV risk profile

G. Pennisi et al. (Università di Palermo, Italy) aimed to evaluate the impact of fatty liver and fibrosis on cardiovascular risk in a general population. They recruited 542 subjects included in the community-based ABCD (Alimentazione, Benessere Cardiovascolare e Diabete) study...
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Sequential combination of NIS-4, MACK-3, and FAST scores

For Y. J. Zhou, et al., there is an urgent need to identify patients who are at risk of developing NASH. Traditional, non-invasive tests have been developed to identify either NASH or advanced fibrosis. However, these tests do not accurately detect patients who are at risk of NASH.
Harrison et al. developed and validated the NIS4 test that provides...
Read MoreSequential combination of NIS-4, MACK-3, and FAST scores

Epidemiology: NAFLD from 1999 to 2018 in China

For J. Zhou et al. (Wuhan University, China), NAFLD has become the most prevalent liver disorder in China but has not received sufficient attention. NAFLD-related advanced liver disease and its mortality along with its overall disease burden are expected to increase substantially. In their meta-analysis, the authors summarise eight...
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NIS4 for non-invasive diagnosis of NASH and liver fibrosis

S. A. Harrison et al. (University of Oxford, UK) report the development and validation of a blood-based diagnostic test to non-invasively rule in and rule out at-risk NASH. In their prospective derivation and global validation study, derivation was done in the discovery cohort, which comprised 239 prospectively recruited patients with...
Read MoreNIS4 for non-invasive diagnosis of NASH and liver fibrosis