Prof. Frank Tacke
Frank Tacke was originally educated at the medical school in Hannover, Germany, and Baylor College of Medicine, Houston, TX. Later he stayed at University of Texas, M.D. Anderson Cancer Center in Houston, working on new gene therapy strategies (1998-1999) as well as for a post-doctoral research training (2004-2006) at the Mount Sinai Medical Center, New York, working on monocyte/macrophage and dendritic cell biology. Since 2006, he is a clinical physician and leader of a research laboratory at the University Hospital Aachen, Germany.
Inflammation in NASH and the transition to HCC: an update on scientific breakthroughs by Dr Peiseler and Prof Tacke, Germany
As the International NASH day draws more attention to NASH, it’s important to remember that hepatocarcinoma (HCC) is the 2nd most common cause of cancer related death. Dr M. Peiseler and Dr F. Tacke, Charité hospital, Berlin, Germany present the latest scientific information about NASH as a systemic disease, represented by a common inflammatory ‘NAFLD phenotype’ of myeloid cells in liver and bone marrow. They highlight the role of inflammation and its multiple markers.
Read MoreInflammation in NASH and the transition to HCC: an update on scientific breakthroughs by Dr Peiseler and Prof Tacke, GermanyNew insights into liver macrophages in NASH pathogenesis
Prof Tacke, Germany reviews the epidemiological challenge of NAFLD and NASH worldwide, especially with the obesity pandemic. He describes the clinical impact of inflammation and fibrosis in NAFLD and the role of macrophages. Finally, he discusses the possible therapeutic implications.
Read MoreNew insights into liver macrophages in NASH pathogenesisThe multiple risks in NAFLD by Prof. F. Tacke
In NAFLD, the liver is both victim and motor of a multisystem disease.
Liver disease is not limited to the liver itself but has an impact on glycemic control in the body.
Prof. Tacke discusses this vicious cycle and how NAFLD may add to coexisting risk factors and is predictor of morbidity and mortality. He shows why this is also important to develop new treatment strategies.
Read MoreThe multiple risks in NAFLD by Prof. F. TackeRole of PPARs (experimental paper) by Prof. F. Tacke
Prof. Frank Tacke discusses a paper in press in the Journal of Hepatology regarding the role of PPAR’s in experimental models and how these PPAR’s affect the progression of liver disease.
Read MoreRole of PPARs (experimental paper) by Prof. F. Tacke
The Role of PPARs in Inflammation
Prof Frank Tacke, Germany, discusses the role of PPARs in adipose tissue and liver inflammation. This video was filmed in Boston during the Liver meeting 2019.
Read MoreThe Role of PPARs in Inflammation
Prof Tacke explains why he feels the basic science part of the Liver meeting 2019 in Boston was exciting
Prof Tacke explains why he feels the basic science part of the Liver meeting 2019 in Boston was exciting
Read MoreProf Tacke explains why he feels the basic science part of the Liver meeting 2019 in Boston was excitingHe is board-certified in Internal Medicine, Gastroenterology and Critical Care Medicine. His research interests are: Clinical and Experimental Hepatology, Liver Immunology, Viral Hepatitis, Gastroenterology, Critical Care Medicine, and Monocyte/Macrophage Biology. In 2012, Frank Tacke was appointed as an Associate Professor (W2-professorship) at the RWTH University Aachen. He has (co‑)authored >180 peer-reviewed original and review articles.
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