NASH Observatory

⏿ The PanNASH Initiative is an interactive web-based platform presenting global NASH statistics to inform NASH control and research.

Serum uric acid level and NAFLD in T2DM patients

This study aimed to investigate the association between serum uric acid level and NAFLD in 583 patients with type 2 diabetes (T2DM) hospitalised in the Department of Hepatology, Yantai Qishan Hospital (China). In this study, multivariate regression analyses demonstrated that after adjusting for confounding factors...

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Sugar and fat increase the risk of advanced liver disease

In this editorial, P. Manka Essen University Hospital, Germany) and W. K. Syn (Medical University of South Carolina, USA) comment a study by Benhammou and colleagues, who evaluated the effects of NAFLD risk factors including obesity and diabetes on the long-term outcomes of patients with HCV treated with direct-acting antivirals...

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Phytomedicines in experimental models of NAFLD

This systematic review aims to investigate the potential multi-targeting effects of plant-derived extracts in experimental models of NAFLD. The authors, A. Ore et al., (Ajayi Crowther University, Oyo, and Federal University of Agriculture, Abeokuta, Nigeria) identified 9 articles fulfilling their inclusion criteria...

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Liver organoid cultures and development of new therapeutic agents

In this review in Japanese, H. Yamamoto et al. (Tokyo University of Agriculture and Technology, Japan) outline the current issues in the diagnosis and treatment of NASH and introduce their research for the discovery of early diagnostic markers and the development of new therapeutic agents using liver organoid cultures derived from mouse models of NASH...

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The Course of Liver Histology and Morbi-Mortality in NAFLD / NASH

Prof.-Manuel-Romero-Gomez

Prof. Manuel Romero-Gomez discusses the course of liver histology and its impact on mortality and morbidity in patients with NAFLD and NASH. He clarifies how fibrosis determines the prognosis of NAFLD and is the main therapeutic target. The importance of steatosis is also discussed both at the early phase and advanced phase. Finally he reviews the association with HCC and CV risks.

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NAFLD patients and PCI: In-hospital outcomes

This study by H. Ali et al. (Rutgers University New Jersey Medical School, USA) aims to explore outcomes in 429,855 patients who underwent percutaneous coronary intervention with or without placement of drug-eluting stents to determine whether the concurrent diagnosis of NAFLD led to worse in-hospital outcomes...
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