MAFLD biomarkers: a review
The identification of high-risk MAFLD patients is paramount. Liver biopsy is still considered the gold standard for the assessment of patients with MAFLD. The search for noninvasive biomarkers .....
Commented Articles
PanNASH covers commented articles ans publications to acquire sufficient information, understanding, and skills to cope with NASH/NAFLD healthcare demands.
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NAFLD/NASH: clinically relevant adipose tissue measurement techniques
The body mass index (BMI) is commonly used as a proxy measure of body fatness. However, BMI does not reflect the level and distribution of body fat. .....
B cells aggravate NASH: an innate and adaptive signalling
In this study, F. Barrow et al. (University of Minnesota Medical School, Minneapolis, USA) report that NASH livers accumulate B cells with elevated pro-inflammatory cytokine secretion .....
NAFLD: from drivers to targets
In this review, A. Santos-Laso et al. (Marqués de Valdecilla University Hospital, Valdecilla Biomedical Research Institute, Santander, Spain) summarise the key aspects of NAFLD .....
NASH: an Overview Through 200 Years of Clinical Research
Although the term 'fatty liver hepatitis' first appeared in 1962, it was in 1980 that the term 'non-alcoholic steatohepatitis' (NASH) was coined and the histopathological.....
Immune cell-mediated features of NASH
In this review, T. Huby and E. L. Gautier (Sorbonne Université, Hôpital de la Pitié-Salpêtrière, Paris, France) discuss “current concepts related to the.....
Steatohepatitis: hypothesis for a pathomechanism
In this article, P. M. Abuja et al. (Medical University of Graz, Austria) propose that steatohepatitis develops in four phases with transitions, priming triggering, adaptation....
Fatty liver through the ages: Nonalcoholic steatohepatitis
In this article, Z. M. Younossi et al. (Inova Health System, Falls Church, VA, USA) aimed to review the current literature on NAFLD and NASH as it impacts children and adults....
Parsing the role of PPARs in macrophage processes
In this review, D. Toobian et al. (University of California San Diego, CA, USA) underline emerging evidence of the potential roles of the PPAR subtypes in macrophage.....
AGA: a NAFLD clinical care pathway
The American Gastroenterological Association assembled a multidisciplinary panel of experts to develop a Clinical Care Pathway providing explicit guidance on the.....
Auto-aggressive CXCR6+ CD8 T cells cause liver immune pathology in NASH
Mechanistic understandings of liver damage in NASH are incomplete. In this article, using a preclinical mouse model that displays key features of human NASH, M.....
T cells: Friends and foes?
In this review, P. Ramadori et al. (German Center for Cancer Research (DKFZ), Heidelberg, Germany) explain the cellular crosstalk of T cells with other immune cells, regulatory.....