B cells aggravate NASH: an innate and adaptive signalling

In this study, F. Barrow et al. (University of Minnesota Medical School, Minneapolis, USA) report that NASH livers accumulate B cells with elevated pro-inflammatory cytokine secretion .....
PUBLISHED IN: Hepatology 2021

Commentary

In this study, F. Barrow et al. (University of Minnesota Medical School, Minneapolis, USA) report that NASH livers accumulate B cells with elevated pro-inflammatory cytokine secretion and antigen-presentation ability.

The authors have identified intrahepatic B-cell accumulation and activation as an important mechanism that contributes to the pathogenesis of NASH by promoting hepatic glucose intolerance, inflammation, and fibrosis, through innate and adaptive immune mechanisms.

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Dr. D. Beard

Dr. D. Beard

Articles: 189

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