Commentary
In this study, F. Barrow et al. (University of Minnesota Medical School, Minneapolis, USA) report that NASH livers accumulate B cells with elevated pro-inflammatory cytokine secretion and antigen-presentation ability.
The authors have identified intrahepatic B-cell accumulation and activation as an important mechanism that contributes to the pathogenesis of NASH by promoting hepatic glucose intolerance, inflammation, and fibrosis, through innate and adaptive immune mechanisms.
