NAFLD: from drivers to targets

In this review, A. Santos-Laso et al. (Marqués de Valdecilla University Hospital, Valdecilla Biomedical Research Institute, Santander, Spain) summarise the key aspects of NAFLD .....
PUBLISHED IN: Biomedicines 2021

Commentary

In this study, F. Barrow et al. (University of Minnesota Medical School, Minneapolis, USA) report that NASH livers accumulate B cells with elevated pro-inflammatory cytokine secretion and antigen-presentation ability.

The authors have identified intrahepatic B-cell accumulation and activation as an important mechanism that contributes to the pathogenesis of NASH by promoting hepatic glucose intolerance, inflammation, and fibrosis, through innate and adaptive immune mechanisms.

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Dr. G. Bozet, MD

Dr. G. Bozet, MD

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