Auto-aggressive CXCR6+ CD8 T cells cause liver immune pathology in NASH

Mechanistic understandings of liver damage in NASH are incomplete. In this article, using a preclinical mouse model that displays key features of human NASH, M.....
PUBLISHED IN: Nature 2021

Commentary

Mechanistic understandings of liver damage in NASH are incomplete. In this article, using a preclinical mouse model that displays key features of human NASH, M. Dudek et al. (Technical University of Munich, Germany) found an indispensable role for T cells in liver immunopathology. The authors detected hepatic accumulation of CD8 T cells with phenotypes that combined tissue residency with effector and exhaustion characteristics in NASH mice and in patients with NASH. Activation of CD8 T cells during NAFL and NASH are attributed to metabolic signals such as acetate and extracellular ATP.

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Dr. G. Bozet, MD

Dr. G. Bozet, MD

Articles: 173

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