COMMENTED ARTICLES

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Endothelial fatty liver binding protein 4: a new targetable mediator in hepatocellular carcinoma related to metabolic syndrome.
This original study demonstrates that liver sinusoidal endothelial cells (LSECs) exposed to conditions mimicking NAFLD -namely high concentrations of glucose, insulin, or VEGFA- release FABP4. They also observed that fatty…
Authors
Laouirem S, Sannier A, Norkowski E, Cauchy F, Doblas S, Rautou PE, Albuquerque M, Garteiser P, Sognigbé L, Raffenne J, van Beers BE, Soubrane O, Bedossa P, Cros J, Paradis V.
Published in
Oncogene. 2019 Apr;38(16):3033-3046.
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Liver microRNA-21 is overexpressed in non-alcoholic steatohepatitis and contributes to the disease in experimental models by inhibiting PPARα expression.
This original study demonstrated that microRNA-21 is overexpressed in the liver of patients with NASH, but not in those with bland steatosis. Liver microRNA-21 in NASH is primarily expressed in inflammatory and biliary cells. Using different mouse models of NASH, authors demonstrated that microRNA-21 contributes to key features of NASH, i.e. cell injury…
Authors
Loyer X, Paradis V, Hénique C, Vion AC, Colnot N, Guerin CL, Devue C, On S, Scetbun J, Romain M, Paul JL, Rothenberg ME, Marcellin P, Durand F, Bedossa P, Prip-Buus C, Baugé E, Staels B, Boulanger CM, Tedgui A, Rautou PE.
Published in
Gut. 2016 Nov;65(11):1882-1894.
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A defect in endothelial autophagy occurs in patients with nonalcoholic steatohepatitis and promotes inflammation and fibrosis.
Autophagy is a physiological process controlling endothelial homeostasis in vascular beds outside the liver. This original study demonstrates that autophagy is defective in liver endothelial cells of patients with NASH and that this defect promotes liver inflammation and fibrosis at early stages of NASH, but also at advanced stages of chronic liver disease…
Authors
Hammoutene A, Biquard L, Lasselin J, Kheloufi M, Tanguy M, Vion AC, Mérian J, Colnot N, Loyer X, Tedgui A, Codogno P, Lotersztajn S, Paradis V, Boulanger CM, Rautou PE.
Published in
A defect in endothelial autophagy occurs in patients with nonalcoholic steatohepatitis and promotes inflammation and fibrosis.
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Molecular pathways between obesity, non-alcoholic steatohepatitis (NASH) and hepatocellular carcinoma (HCC).
This article highlights the importance of the recent study by Grohmann et al. published in the November, 2018 issue of Cell. It contributes to the understanding of molecular mechanisms which relate obesity with NASH and HCC. This study…
Authors
Petrucciani N, Gugenheim J.
Published in
Hepatobiliary Surg Nutr 2019;8:395-397.
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Pediatric Fatty Liver Disease
Reports of NAFLD in patients as young as 2 years of age have been documented. It tends to be more common in children who are obese but has been known to occur in patients who have normal weight. Children with NAFLD are at increased…
Authors
Jain A
Published in
Mo Med 2019;116:123-128.
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Short sleep duration is a risk of incident nonalcoholic fatty liver disease: a population-based longitudinal study.
Previous cross-sectional studies revealed that short sleep duration has a close relationship with the presence of non-alcoholic fatty liver disease (NAFLD). This historical cohort study of 12,306 participants is the first study…
Authors
Okamura T, Hashimoto Y, Hamaguchi M, et al
Published in
J Gastrointestin Liver Dis 2019;28:73-81.
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Can Nonfibrotic Nonalcoholic Steatohepatitis Be Effectively Identified by Supersonic Shear Imaging?
Supersonic shear imaging (SSI) is a relatively new technique to measure the elasticity of target tissues based on the shear wave propagation. In this study, J. Yang et al. aimed to evaluate the value of SSI in discriminating NASH…
Authors
Yang J, Lin L, Xue E, et al.
Published in
Anal Cell Pathol (Amst) 2019;2019:2013674.
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Depression is associated with non-alcoholic fatty liver disease among adults in the United States.
To determine whether depression is associated with NAFLD and NAFLD-related advanced fibrosis in a large population sample, D. Kim et al. performed a cross-sectional analysis using the 2007-2016 NHAHES database among adults…
Authors
Kim D, Yoo ER, Li AA, et al.
Published in
Aliment Pharmacol Ther 2019.
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A new method to induce nonalcoholic steatohepatitis (NASH) in mice.
F. Savari et al. studied the effect of fructose, fat-rich and Western diet feeding along with aggravative effect of cigarette smoking on liver status in 64 male mice. The mice were assigned into 4 groups that fed standard…
Authors:
Savari F, Mard SA, Badavi M, et al.
Published in:
BMC Gastroenterol 2019;19:125.
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A Review of Non-Alcoholic Fatty Liver Disease in HIV-Infected Patients: The Next Big Thing?
The burden of liver-related morbidity remains high among HIV-infected patients, with a prevalence of up to 50%. The pathogenesis of NAFLD and the reasons for progression to non-alcoholic steatohepatitis (NASH) are still…
Authors
van Welzen BJ, Mudrikova T, El Idrissi A, et al.
Published in
Infect Dis Ther 2019;8:33-50.
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Risks and clinical predictors of cirrhosis and hepatocellular carcinoma diagnoses in adults with diagnosed NAFLD: real-world study of 18 million patients in four European cohorts.
M Alexander et al. used healthcare records of 18 million adults to estimate the risk of acquiring advanced liver disease diagnoses in patients with NAFLD or NASH compared to individually matched controls. Data were extracted…
Authors
Alexander M, Loomis AK, van der Lei J, et al.
Published in
BMC Med 2019;17:95
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Role of liver sinusoidal endothelial cells in non-alcoholic fatty liver disease
Liver sinusoidal endothelial cells (LSECs) are highly specialized endothelial cells localized at the interface between the blood derived from the gut and the adipose tissue on the one side, and other liver cells on the other side…
Authors
Hammoutene A, Rautou PE.
Published in
J Hepatol 2019;70:1278-1291.
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Platelet GPIbα is a mediator and potential interventional target for NASH and subsequent liver cancer.
Here, the authors show that platelet number, platelet activation and platelet aggregation are increased in NASH but not in steatosis or insulin resistance. Platelet cargo, platelet adhesion and platelet activation…
Authors
Malehmir M, Pfister D, Gallage S, Szydlowska M, et al.
Published in
Nat Med. 2019 Apr;25(4):641-655.
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Biological mechanisms and related natural modulators of liver X receptor in nonalcoholic fatty liver disease.
In this review, the authors discuss the mechanisms of LXR in NASH and summarize the natural products reported to modulate NAFLD via LXR or the LXR pathway, offering an alternative approach for LXR-related drug development…
Authors
Ni M, Zhang B, Zhao J, Feng Q, Peng J, Hu Y, Zhao Y
Published in
Biomed Pharmacother. 2019 May 113
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Role of Vitamin E for Nonalcoholic Steatohepatitis in Patients With Type 2 Diabetes: A Randomized Controlled Trial.
This proof of concept study was designed to assess if vitamin E, alone or combined with pioglitazone, improves histology in patients with T2DM and NASH. It showed no effect of vitamin E on ballooning or inflammation, although some effect…
Authors
Bril F et al.
Published in
Diabetes Care 2019
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A review of the studies on food-derived factors which regulate energy metabolism via the modulation of lipid-sensing nuclear receptors.
In this review, the author describes current knowledge of the role of PPARs in the regulation of whole-body energy metabolism and several examples of food factors that act as ligands of PPARs, which may be useful in the management of obesity…
Authors
Goto T.
Published in
Biosci Biotechnol Biochem. 2019 Apr;83(4):579-588. Epub 2018 Dec 20.
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Nutritional Intake and the Risk for Non-Alcoholic Fatty Liver Disease (NAFLD) .
The editorial accompanying a special issue of nutrition in NAFLD, highlights the relevance of the topic and open issues for future studies…
Authors
Schattenberg JM, Bergheim I .
Published in
Nutrients 2019.
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Pharmacological treatments of the “Fibrotic-NASH”: Towards a delivery on time?
The molecular mechanisms involved in the development and progression of NAFLD are complex and multi- factorial. Intrahepatic but also extrahepatic mechanisms play an important role. In the future, pharmacological innovations may be available for patients with fibrotic-NASH. An increasing number of pre-clinical and clinical studies are in progress targeting…
Authors
Gual P
Published in
Clin Res Hepatol Gastroenterol 2019.
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Crosstalk between adipose tissue insulin resistance and liver macrophages in Non Alcoholic Fatty Liver Disease
Elisabetta Bugianesi et al. undertook this study to elucidate the interplay between macrophage activation, insulin resistance in target organs and tissues and hepatic damage.In 40 non-diabetic patients with biopsy-proven NAFLD…
Authors
Rosso C, Kazankov K, Younes R, et al.
Published in
Journal of hepatology 2019.
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Non-alcoholic fatty liver disease in non-obese individuals: Prevalence, pathogenesis and treatment
A remarkable number of lean individuals in the United States suffer from NAFLD, likely due to distinct components of MetS, such as diabetes and/or hypertension.Indeed, as noticed in the Kangbuk Samsung Health Study, 16,279 non-obese patients with different grades of liver…
Authors
Molina-Molina E, Krawczyk M, Stachowska E, et al.
Published in
Clin Res Hepatol Gastroenterol 2019.
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Non-alcoholic fatty liver disease in non-obese individuals: Prevalence, pathogenesis and treatment
This article summarizes the (mainly preclinical) evidence of the role of adipose tissue inflammation and NAFLD via macrophages that play an important role in connecting adipose tissue inflammation to liver inflammation…
Authors
Lefere, S and Tacke, F
Published in
Lefere, S and Tacke, F
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Pioglitazone Discontinuation in Patients with Nonalcoholic Steatohepatitis (NASH) Is Associated withDisease Recurrence
ioglitazone (PIO) is effective for long-term treatment of patients with nonalcoholic steatohepatitis(NASH) with prediabetes or type 2 diabetes. It reduces liver fibrosis and increases adipose tissue insulin sensitivity…
Authors
Bril F, Cusi K et al
Published in
Diabetes 2019 Jun; 68 (Supplement 1)
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Natural Killer Cells and Type 1 Innate Lymphoid Cells Are New Actors in Non-alcoholic Fatty Liver Disease
Lipid accumulation in the liver contributes to hepatocyte cell death and promotes liver injury. Local immune cells are activated either by Danger Associated Molecular Patterns (DAMPS) released by dead hepatocytes or by bacterial…
Authors
Luci C, Vieira E, Perchet T, et al.
Published in
Front Immunol 2019;10:1192.
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Modulation of Insulin Resistance in NAFLD
Since there is a close relationship between insulin resistance and NAFLD, modulation of insulin resistance has a considerable interest in the quest for effective treatments of NAFLD. This review article focuses on possible mechanisms…
Authors
Khan, R. , Bril, F. , Cusi, K. and Newsome, P
Published in
Hepatology. 2018 Dec 16 doi: 10.1002/hep.30429. [Epub ahead of print].
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Non-alcoholic fatty liver disease and the interface between primary and secondary care.
The prevalence of Non-alcoholic fatty liver disease (NAFLD) is estimated to be 25–30% in unselected populations. Its prevalence is high but severity is low. However, many patients are now referred to hepatology departments…
Authors
Emmanuel A Tsochatzis and Philip N Newsome .
Published in
in Lancet Gastroenterol Hepatol 2018; 3: 509–17.
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