COMMENTED ARTICLES

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NASH: bariatric surgery and major adverse liver and cardiovascular outcomes
In this retrospective cohort study of 1158 patients with biopsy-proven fibrotic NASH without cirrhosis, bariatric surgery was significantly associated with a lower risk of major adverse liver outcomes and major adverse cardiovascular events. For the authors, in this study….
Reviewed by
G. Bozet, MD
Authors
Aminian A, Al-Kurd A, Wilson R, et al.
Published in
JAMA 2021
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Pathogenesis of NASH and dynamic changes in liver macrophages
Macrophage-mediated inflammation is critical in the pathogenesis of NASH. T-cell immunoglobulin domain and mucin domain-4 (TIM-4) is selectively expressed on antigen-presenting cells and modulates various immune responses. However, the role of TIM-4 expressed by Kupffer cells in liver fibrosis remains unclear….
Reviewed by
D. Beard
Authors
Daemen S, Gainullina A, Kalugotla G, et al.
Published in
Cell reports 2021
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NAFLD: progressive liver fibrosis
The progression of NASH was initially defined according to a two-hit model involving an initial development of steatosis, followed by a process of lipid peroxidation and inflammation. In contrast, current evidence proposes a “multi-hit” or “multi-parallel hit” model that includes multiple pathways….
Reviewed by
G. Bozet, MD
Authors
Ramai D, Facciorusso A, Vigandt E, et al.
Published in
Cells 2021
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NAFLD risk may be associated to dementia and cognitive decline in older age
The present study aimed to investigate the relationship between NAFLD risk and a dementia diagnosis in a large population-based sample aged >65 years. These findings suggest that “an increased NAFLD risk may be associated to dementia and cognitive decline in older age….
Reviewed by
D. Beard
Authors
Lampignano L, Donghia R, Griseta C, et al.
Published in
Front Aging Neurosci 2021
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Advancing the global public health agenda for NAFLD
In this global Delphi study, a multidisciplinary group of experts developed consensus statements and recommendations. The resulting consensus statements and recommendations address a broad range of topics that have general relevance for policymakers, health-care practitioners, civil society groups, research institutions….
Reviewed by
G. Bozet, MD
Authors
Lazarus JV, Mark HE, Anstee QM, et al.
Published in
Nat Rev Gastroenterol Hepatol 2022
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NASH: mobile health intervention for lifestyle modification
Lifestyle modification designed to achieve sustained, modest weight loss remains hopelessly difficult to accomplish for many of patients with NAFLD. Mobile health application use to augment current educational practices will achieve meaningful dietary change and regular physical activity….
Reviewed by
D. Beard
Authors
Faust A, Stine JG
Published in
Dig Dis Sci 2021
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NAFLD name change: Requiem or Reveille?
In this cross-sectional analysis of the National Health and Nutrition Examination Surveys, 2017-2018, E. Vilar-Gomez et al. (University School of Medicine, USA) examined the association between diet quality, physical activity, socioeconomic status, and NAFLD risk…
Reviewed by
D. Beard
Authors
Singh SP, Anirvan P, Khandelwal R, et al.
Published in
J Clin Transl Hepatol 2021
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Major depressive disorder and NAFLD: the interaction mechanisms
In this cross-sectional analysis of the National Health and Nutrition Examination Surveys, 2017-2018, E. Vilar-Gomez et al. (University School of Medicine, USA) examined the association between diet quality, physical activity, socioeconomic status, and NAFLD risk…
Reviewed by
G. Bozet, MD
Authors
Shao Q, Wu Y, Ji J, et al.
Published in
Front Psychiatry 2021
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Diet, physical activity, education level and NAFLD risk
In this cross-sectional analysis of the National Health and Nutrition Examination Surveys, 2017-2018, E. Vilar-Gomez et al. (University School of Medicine, USA) examined the association between diet quality, physical activity, socioeconomic status, and NAFLD risk…
Reviewed by
G. Bozet, MD
Authors
Vilar-Gomez E, Nephew LD, Vuppalanchi R, et al.
Published in
Hepatology 2021
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Coffee consumption and NAFLD: A systematic review
The effects of coffee consumption on hepatic outcomes are controversial. This study investigated the associations between coffee consumption and the incidence of NAFLD in the general population and the reduction of liver fibrosis among patients with NAFLD…
Reviewed by
D. Beard
Authors
Kositamongkol C, Kanchanasurakit S, Auttamalang C, et al.
Published in
Front Pharmacol 2021
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NAFLD and CV disease among US adults
In this study, S. Ciardullo et al. (Università degli Studi di Milano Bicocca, Italy) present a population-based cross-sectional study including 2734 US adults using data from the 2017-2018 cycle of the National Health and Nutrition Examination Survey The authors show that “patients with NAFLD have….
Reviewed by
G. Bozet, MD
Authors
Ciardullo S, Cannistraci R, Mazzetti S, et al.
Published in
Front Endocrinol (Lausanne) 2021
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Gut microbiome and fatty liver disease
This article describes the complex interactions occurring between diet, the gut microbiome, and bile acids in the aetiology of fatty liver disease. Emerging new molecular technologies may provide guidance in unraveling the complex physiological pathways driving fatty liver disease and better….
Reviewed by
D. Beard
Authors
Hylemon PB, Su L, Zheng PC, et al.
Published in
Compr Physiol 2021
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NAFLD: recent guideline updates
In this review, Yumi Ando and Janice H. Jou (Portland, OR, USA) summarise updated guidelines and guidance recommendations for the management of adult NAFLD. Interestingly, the authors highlight key difference between US, Asian, and European recommendations; and provide key updates….
Reviewed by
G. Bozet, MD
Authors
Ando Y, Jou JH.
Published in
Clin Liver Dis (Hoboken) 2021
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Hepatic fibrosis and CV risk factors: the Framingham Heart Study
Although liver fat is associated with cardiovascular risk factors, the association between hepatic fibrosis and cardiovascular risk factors is less clear. M. T. Long et al. (Boston University School of Medicine, USA) performed vibration-controlled transient elastography, assessing controlled attenuation parameter…
Reviewed by
D. Beard
Authors
Long MT, Zhang X, Xu H, et al.
Published in
Hepatology 2021
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Awareness for NAFLD and interdisciplinary care paths
NAFLD is an increasingly prevalent and potentially severe liver disease, emphasising the need for implementation of widely supported care paths for patients at risk for advanced stages of NAFLD. In this review article by A. M. van Dijk et al. (Amsterdam University Medical Centre, The Netherlands), after…
Reviewed by
G. Bozet, MD
Authors
van Dijk AM, Schattenberg JM, Holleboom AG, et al.
Published in
United European Gastroenterol J 2021
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NAFLD and cardiovascular disease
This brief review by Kathleen E. Corey et al. (Liver Center, Massachusetts General Hospital, Boston, MA, USA) provides a pragmatic guide of cardiovascular disease in NAFLD, with a focus on coronary heart disease…
Reviewed by
D. Beard
Authors
Przybyszewski EM, Targher G, Roden M, et al.
Published in
Clin Liver Dis (Hoboken) 2021
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NAFLD: Korean clinical practice guidelines
These Korean guidelines, organised in accordance with proposals by the approval of the Korean Association for the Study of the Liver (KASL) Board of Executives, provide clinical information and direction to healthcare providers involved in the diagnosis and treatment of NAFLD patients. …
Reviewed by
G. Bozet, MD
Authors
Kang SH, Lee HW, Yoo JJ, et al.
Published in
Clin Mol Hepatol 2021
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NASH: prevalence and incidence of non-liver comorbidities in South Korea
Using a meta-analytic approach, J. Park et al. (Santa Clara Valley Medical Center, San Jose, CA, USA) aimed to describe NAFLD incidence and prevalence, NAFLD fibrosis prevalence, and incidence of non-liver comorbidities. In this study, the overall prevalence of NAFLD was 31.46% with an incidence rate of 42.8 per 1,000 person-years…
Reviewed by
D. Beard
Authors
Park J, Lee EY, Li J, et al.
Published in
Dig Dis 2021
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NAFLD beyond the liver
The majority of NAFLD patients die of cardiovascular disease. For this reason, management of this condition requires a multidisciplinary team. However, important misconceptions remain among primary care providers. NAFLD should be understood as part of a systemic disease characterized …
Reviewed by
G. Bozet, MD
Authors
Godinez-Leiva E, Bril F.
Published in
Curr Hypertens Rev 2021
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Evidence linking obesity with MAFLD, NASH, and CVD
Several studies provide evidence for an association between MAFLD and atherosclerosis and cardio-metabolic disorders, including cardiovascular diseases such as coronary heart disease and stroke. Therefore, the combination of MAFLD/NASH is associated with vascular risk and CVD progression, but the underlying mechanisms…
Reviewed by
D. Beard
Authors
Gutiérrez-Cuevas J, Santos A, Armendariz-Borunda J.
Published in
Int J Mol Sci 2021
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Physical activity and NAFLD: a mini-review
Exercise could mediate its beneficial effects directly on the liver and indirectly via extrahepatic pathways, forming a dose-response relationship with NAFLD in terms of prevalence and disease severity…
Reviewed by
G. Bozet, MD
Authors
Cigrovski Berkovic M, Bilic-Curcic I, Mrzljak A, et al.
Published in
Front Nutr 2021
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NAFLD and risk of sarcopenia: a prospective study
The authors evaluated the impact of NAFLD on the risk of low muscle mass and low muscle strength in a nationwide multicentre study in a total of 1595 community-dwelling people aged 70-84 years were followed for 2 years in the Korean Frailty and Aging Cohort Study…
Reviewed by
D. Beard
Authors
Roh E, Hwang SY, Yoo HJ, et al.
Published in
Hepatol Int 2021
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Treatments for NAFLD: different available approaches
General strategies have been proposed to manage NAFLD. They include: (a) lifestyle change in order to promote weight loss by diet and physical activity, (b) control of the main cardiometabolic risk factors, (c) correction of all modifiable risk factors leading the development and progression of advanced forms of NAFLD, (d) and prevention…
Reviewed by
G. Bozet, MD
Authors
Mantovani A, Dalbeni A.
Published in
Int J Mol Sci 2021
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Liver Fibrosis in NAFLD: future diagnostic biomarkers and anti-fibrotic drugs
A few studies investigated the Mediterranean diet in developing countries, especially middle east countries where dietary patterns are different from other parts of the world. This case-control study aimed to examine the association between adherence to the Mediterranean diet and NAFLD in Iranian adults…
Reviewed by
D. Beard
Authors
Entezari MR, Talenezhad N, Mirzavandi F, et al.
Published in
J Nutr Sci 2021
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Liver Fibrosis in NAFLD: future diagnostic biomarkers and anti-fibrotic drugs
In this review, L. J. M. Heyens et al. (Hasselt University, Belgium, Maastricht University, Netherlands, and, Ziekenhuis Oost-Limburg, Belgium) give an overview of the pathogenic mechanisms of the evolution from isolated steatosis to fibrosis. The authors also discuss of the current and future diagnostic biomarkers and anti-fibrotic drugs…
Reviewed by
G. Bozet, MD
Authors
Heyens LJM, Busschots D, Koek GH, et al.
Published in
Front Med (Lausanne) 2021
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Increased portal pressure in non-cirrhotic NAFLD: a review
“Should we be concerned about the presence of increased portal pressure in non-cirrhotic NAFLD? What would be a safe, easy, and accurate way to detect subclinical portal hypertension and utilise it in risk assessment? How could an early rise in portal pressure contribute to NAFLD pathophysiology and could these mechanisms identify novel therapeutic targets?” This article by G. Baffy…
Reviewed by
D. Beard
Authors
Baffy G, Bosch J.
Published in
J Hepatol 2021
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NAFLD/NASH-related liver fibrosis: from mechanisms to prevention
While the successful treatment of hepatitis B and C reduced the burden of liver disease related to viral hepatitis, NAFLD) or NASH) are nowadays the leading causes of hepatic fibrosis worldwide. In this review, F. Tacke et al. (Charité University Medicine, Berlin, Germany) discuss recent advances in antifibrotic prevention and therapy…
Reviewed by
G. Bozet, MD
Authors
Tacke F, Weiskirchen R.
Published in
Ann Transl Med 2021
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NASH: a complex disease
In this review, J. L. Fraile et al. (University of Aberdeen, UK) have performed an exhaustive review of the current therapeutic landscape (drug classes, biologics vs small molecules, and target molecules) for NASH. Regarding lanifibranor, the authors stated, “it’s an oral small molecule that activates…
Reviewed by
D. Beard
Authors
Fraile JM, Palliyil S, Barelle C, et al.
Published in
Drug Des Devel Ther 2021
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NASH: Dietary interventions, a meta-analysis
In their systematic review and meta-analysis, V. Houttu et al. (Amsterdam University Medical Center, The Netherlands) summarise and assess the evidence for dietary interventions NAFLD patients. In these patients, Mediterranean and hypocaloric dietary interventions favouring unsaturated fatty acids …
Reviewed by
G. Bozet, MD
Authors
Houttu V, Csader S, Nieuwdorp M, et al.
Published in
Front Nutr 2021
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NASH and dietary patterns: a meta-analysis
S. Hassani Zadeh et al. (Shahid Sadoughi University of Medical Sciences, Yazd, Iran) carried out this meta-analysis to examine the association between dietary patterns and NAFLD. The authors selected three dietary patterns of Western, Prudent, and Mediterranean. The Prudent diet curtails the intake of eggs, whole milk, and whole milk-based dairy products, liver…
Reviewed by
D. Beard
Authors
Hassani Zadeh S, Mansoori A, Hosseinzadeh M.
Published in
J Gastroenterol Hepatol 2021
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Outcomes of NAFLD and MAFLD: Results from a community-based, prospective cohort study
In an ongoing, community-based, cohort-study in Sri Lanka, participants were randomly selected in 2007, and were reassessed in 2014 to evaluate new-onset metabolic traits and cardiovascular-events. M. A. Niriella et al. (University of Kelaniya, Sri Lanka) compared baseline characteristics, metabolic traits and cardiovascular-events after…
Reviewed by
G. Bozet, MD
Authors
Niriella MA, Ediriweera DS, Kasturiratne A,
et al.
Published in
PLoS One 2021
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Mortality in NAFLD or MAFLD patients
In order to compare the outcomes of the two diagnostic criteria in a population-based study, Q. Huang et al. (Peking University People’s Hospital, Beijing, China) aimed to investigate the association of MAFLD or NAFLD with all-cause and cause-specific mortality. They recruited 12,480 participants from the Third National Health and Nutrition…
Reviewed by
D. Beard
Authors
Huang Q, Zou X, Wen X, et al.
Published in
Front Med (Lausanne) 2021
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