Ppar Science Articles

📰 PPARS are being extensively investigated in the treatment of NAFLD/NASH, discover more through our PPAR science articles.

Emerging drugs targeting specific points in NASH pathogenesis

Authors: Stojsavljevic-Shapeski S, Duvnjak M, Virovic-Jukic L,
et al.
Published in J Clin Transl Hepatol 2021
Extensive research and revelation in the field of pathogenesis of NASH has offered new possibilities of treatment and emerging new drugs that are being tested currently in numerous preclinical and clinical trials. These drugs target almost all steps in the pathogenesis of NASH...
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PPARs as candidates for the treatment of NAFLD

Authors: Fougerat A, Montagner A, Loiseau N, et al
Published in Cells 202
The prevalence of NAFLD is dramatically increasing in developed countries, but no approved therapy is available. Most of the current pharmacological strategies target comorbidities, such as manifestations of metabolic syndrome. In addition, none of used medications improve fibrosis, which is the strongest indicator of mortality in NAFLD...
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Pan-PPAR agonist lanifibranor improves portal hypertension and hepatic fibrosis in experimental advanced chronic liver disease

Authors: Boyer-Diaz Z, Aristu-Zabalza P, Andrés-Rozas M, et al.
Published in J Hepatol 2020
Advanced chronic liver disease (ACLD) is a serious public health issue for which a safe and effective treatment is still lacking. It is often associated with portal hypertension and liver fibrosis. Over the recent years, peroxisome proliferator-activated receptors family (PPARs) have been considered as a relevant...
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PPARs and immune responses

Authors: Christofides A, Konstantinidou E, Jani C, et al.
Published in Metabolism 2020
Peroxisome proliferator-activated receptors (PPARs) are fatty acid-activated transcription factors of nuclear hormone receptor superfamily that regulate energy metabolism. Currently, three PPAR subtypes have been identified: PPARα, PPARγ, and PPARβ/δ. PPARα and PPARδ are highly expressed in oxidative tissues and regulate genes involved in substrate delivery...
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Peroxisome proliferator-activated receptors and their novel ligands as candidates for the treatment of non-alcoholic fatty liver disease

Authors: Fougerat A, Montagner A, Loiseau N, et al.
Published in Cells 2020
anifibranor is a moderately potent and well-balanced modulator of the three PPAR isotypes and has a good safety profile. Beneficial effects of lanifibranor on NASH histology, including reduced fibrosis, were confirmed recently in a preclinical model of NASH and fibrosis (choline-deficient amino acid-defined HFD mouse model)...
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Experimental steatohepatitis: lanifibranor early reduces NASH activity and macrophage infiltration.

Authors: Lefere S, Puengel T, Hundertmark J, et al.
Published in J Hepatol 2020
In a CDAA-HFD (choline-deficient, amino acid-defined high-fat diet-induced) model, which induces severe inflammation and liver fibrosis, S. Lefere et al. studied the efficacy of single and pan-PPAR agonists in the treatment of progressive steatohepatitis. To examine the pathophysiological sequence of steatohepatitis...
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Differential effects of selective- and pan-PPAR agonists on experimental steatohepatitis and hepatic macrophages.

Authors: Lefere S, Puengel T, Hundertmark J, et al.
Published in J Hepatol 2020
In an experimental study, S. Lefere et al. investigated the efficacy of single and pan-PPAR agonists in the treatment of progressive steatohepatitis. The authors employed the CDAA-HFD (choline-deficient, amino acid-defined high-fat diet-induced) model, which induces severe inflammation and liver fibrosis...
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Human hepatic in vitro models reveal distinct anti-NASH potencies of PPAR agonists.

Authors: Boeckmans J, Natale A, Rombaut M, et al.
Published in Cell Biol Toxicol 2020
In this study, J. Boeckmans et al. (Faculty of Medicine and Pharmacy, Vrije Universiteit, Brussels, Belgium) reproduced key NASH characteristics in vitro by exposing primary human hepatocytes, human skin stem cell-derived hepatic cells, HepaRG and HepG2 cell lines, as well as LX-2 hepatic stellate cells to multiple factors that play a role in the onset of NASH...
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