Commented Articles

The aim of this retrospective cohort study was to develop a risk nomogram for NAFLD in a Chinese population with T2DM. A questionnaire survey, physical examination and biochemical indicator testing were performed on 874 patients with T2DM...

For many years, double-layer phospholipid membrane vesicles, released by most cells, were not considered to be of biological significance. This stance has dramatically changed with the recognition of extracellular vesicles (EVs) as carriers of biologically active molecules that can traffic to local or distant targets and execute defined biological functions...

Cardiovascular death is an important cause of mortality in end stage liver disease patients undergoing orthotopic liver transplant. Left ventricular diastolic dysfunction is often the early manifestation of cirrhotic cardiomyopathy. In order to understand the risk factors for ventricular diastolic dysfunction in end stage liver disease patients...

The topic of liver biopsy in clinical studies, such as for treatments for NASH, is highly important. Despite limitations, liver biopsy remains the gold standard for the study of liver disease. It is important for the exclusion of alternative diseases and co-morbidities such as autoimmune hepatitis or primary biliary cholangitis...

Coffee consumption may have a protective impact on NAFLD and liver fibrosis. However, the evidence from the previous studies is inconsistent. This study comprises two meta-analyses. The first meta-analysis summarizes the effect of coffee consumption on NAFLD in patients who did or did not drink coffee...

Excessive fructose intake causes dysbiosis and tight-junction proteins downregulation, resulting in intestinal-barrier deterioration and low-grade endotoxaemia. Fructose consumption stimulates hepatosteatosis and, when combined with other risk factors, can cause steatohepatitis and even hepatocellular carcinoma. It is well established...

Obstructive sleep apnea (OSA) is associated with the development and evolution of NAFLD, independent of obesity or other shared risk factors. The OSA–NAFLD association is related to the degree of nocturnal hypoxaemia in OSA. Animal models have largely focused on intermittent hypoxia, a key manifestation of OSA...

Several scores based on easily measurable biochemical and clinical parameters, including the fatty liver index (FLI), hepatic steatosis index (HSI), lipid accumulation product (LAP), and NAFLD liver fat score (LFS), have been developed for the detection of NAFLD. However, comparative information regarding the efficacy of these scores for predicting NAFLD...

Two new position papers convincingly propose that non-alcoholic fatty liver disease needs a new name — metabolic associated fatty liver disease (MAFLD). A new name for this disease affecting nearly one billion people globally is overdue, as knowledge gained from the past decades has definitely demonstrated that MAFLD is a purely metabolic disorder...

Several studies have investigated the association between serum uric acid and metabolic syndrome / NAFLD. Four meta-analysis on retrospective and prospective studies confirmed this association, especially in women. However, most of the studies included in the analysis were performed on Asian populations. Despite high quality and large population...