Several studies have investigated the association between serum uric acid and metabolic syndrome / NAFLD. Four meta-analysis on retrospective and prospective studies confirmed this association, especially in women. However, most of the studies included in the analysis were performed on Asian populations. Despite high quality and large population of European studies, they were targeted mainly on the diagnostic aspects of metabolic syndrome.
The aim of this retrospective study by Roberto Catanzaro et al. (Department of clinical and experimental Medicine, University of Catania, Italy) was to investigate the overlap between NAFLD, metabolic syndrome, and hyperuricemia also in a population of Southern Europe. They have found a significant correlation between NAFLD and hyperuricemia. The higher serum uric acid levels accompanied the risk of NAFLD.