Commented Articles

PanNASH covers commented articles ans publications to acquire sufficient information, understanding, and skills to cope with NASH/NAFLD healthcare demands.

Management Articles Commented Articles NASH Observatory

Liver organoid cultures and development of new therapeutic agents

In this review in Japanese, H. Yamamoto et al. (Tokyo University of Agriculture and Technology, Japan) outline the current issues in the diagnosis and treatment of NASH and introduce their research for the discovery of early diagnostic markers and the development of new therapeutic agents using liver organoid cultures derived from mouse models of NASH...

ByDr. G. Bozet, MD
OnOctober 27, 2021

NASH Observatory Commented Articles

Review: MAFLD prevalence in children and adolescents

MAFLD is the most common cause of chronic liver disease in children and adolescents. The risk factors for MAFLD may be prenatal, such as genetic factors, or postnatal, such as obesity and insulin resistance. MAFLD is increasingly recognized in children and adolescents...

ByDr. D. Beard
OnOctober 27, 2021

NASH Observatory Commented Articles Comorbidities Articles

NASH and exposure to cigarette smoking

Consumption of diet rich in fat and cigarette smoking are independent risk factors of NASH and they often occur together in some populations. The present study by S. Fouda et al. (RMIT University, Melbourne, Australia) investigated the mechanisms of high fat diet and cigarette smoking, individually and in combination...

ByDr. G. Bozet, MD
OnOctober 25, 2021

NASH Observatory Commented Articles

Current state and future possibilities in liver transplantation

In this article, S. Rademacher et al. (University of Leipzig Medical Center, Germany) point that liver cirrhosis due to NASH, alcoholic liver disease and hepatocellular carcinoma in cirrhosis are now among the leading indications for liver transplantation...

ByDr. D. Beard
OnOctober 25, 2021

NASH Observatory Commented Articles Comorbidities Articles

NAFLD patients and PCI: In-hospital outcomes

This study by H. Ali et al. (Rutgers University New Jersey Medical School, USA) aims to explore outcomes in 429,855 patients who underwent percutaneous coronary intervention with or without placement of drug-eluting stents to determine whether the concurrent diagnosis of NAFLD led to worse in-hospital outcomes...

ByDr. G. Bozet, MD
OnOctober 21, 2021

Management Articles Commented Articles NASH Observatory

Physical activity, cardiorespiratory fitness and NAFLD

High levels of physical activity and cardiorespiratory fitness may protect against NAFLD. C. J. Kerr et al. (University of Essex, UK) investigated whether different physical activity intensities, and cardiorespiratory fitness, were independent predictors of non-alcoholic fatty liver disease...

ByDr. D. Beard
OnOctober 21, 2021

NASH Observatory Commented Articles

Meta-analysis: coffee consumption and NAFLD

This meta-analysis by U. Hayat et al. (University of Kansas School of Medicine, USA) summarizes available literature about the protective impact of coffee consumption on NAFLD and liver fibrosis. This meta-analysis revealed a 23% decreased risk of development of NAFLD among patients who drank coffee regularly...

ByDr. G. Bozet, MD
OnOctober 14, 2021

NASH Observatory Commented Articles

Lung transplantation recipients with NAFLD

Advanced hepatic fibrosis and cirrhosis are absolute contraindications to lung transplantation. In a retrospective analysis of 150 transplanted patients, A. J. Trindade et al. (Brigham and Women’s Hospital/Harvard Medical School, and Vanderbilt University Medical Center, USA) aimed to determine if mild-moderate NAFLD contributes to increased adverse outcomes...

ByDr. D. Beard
OnOctober 14, 2021

Commented Articles Pathophysiology Articles

NAFLD and hepatic sexual dimorphism

This review by Philippe Lefebvre and Bart Staels (INSERM, CHU Lille, Institut Pasteur de Lille, France) discusses the accumulating evidence of sexual dimorphism in NAFLD. Liver pathophysiology is sexually dimorphic, and male individuals predominantly show more severe stages of non-alcoholic fatty liver, NASH and fibrosis than do female individuals...

ByDr. G. Bozet, MD
OnOctober 12, 2021

Management Articles Commented Articles

Meta-analysis: NAFLD and melatonin supplementation

This meta-analysis was conducted to evaluate the effect of melatonin on liver indices in patients with NAFLD. The results showed that melatonin had a significant effect on aspartate aminoteransferase , alkaline phosphatase, and gamma-glutamyltransferase, but no significant effect on alanine aminotransferase...

ByDr. D. Beard
OnOctober 12, 2021

Commented Articles Comorbidities Articles

NAFLD prevalence in Type 1 diabetes patients

The authors reviewed and screened references in order to estimate NAFLD prevalence in patients with type 1 diabetes, and to explore associated characteristics and outcomes. According to this review, NAFLD prevalence in patients with type 1 diabetes is considerable and is highly dependent on the specific diagnostic modality...

ByDr. G. Bozet, MD
OnSeptember 22, 2021

Commented Articles Comorbidities Articles

Fatty liver index and risk of hypertension

Little data are showing the association between NAFLD and hypertension in a large-scale cohort study. J. H. Roth et al. (Chungnam National University School of Medicine, Daejeon, Korea) evaluated the ability of the fatty liver index to predict the development of hypertension in healthy individuals, in a large cohort of 334,280 healthy individuals...

ByDr. D. Beard
OnSeptember 22, 2021