NAFLD unawareness in US adults

S. A. Alqahtani et al. (King Faisal Specialist Hospital and Research Centre, Saudi Arabia; Johns Hopkins University, USA) aimed to understand public awareness of NAFLD and its temporal trends.
They included 11,700 adults from five National Health and Nutrition Examination Surveys (2007-2016).
From 2007-2008 to 2015-2016, awareness of liver disease among adults with NAFLD improved from 4.4% to 6.3%, but 4 to 10 times lower than awareness about viral hepatitis. In 2015-2016, among
adults with NAFLD, awareness of liver disease was low among young adults and among non-Hispanic Blacks.
Nearly 96% of adults with NAFLD in the USA were unaware they had liver disease, especially among young adults and non-Hispanic Blacks.

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Identifying patients with high-risk NASH: three ultrasound markers

Identifying patients with high-risk-NASH who are candidates for pharmacologic therapy remains a challenge. K. Sugimoto et al. (Tokyo Medical University, Japan) aimed to develop a score to identify patients with a NAFLD activity score of 4 or greater and clinically significant fibrosis.
In this cross-sectional study, the most predictive model combined three ultrasound markers: liver stiffness, attenuation coefficient, and dispersion slope. It showed a positive predictive value of 86.5% and a negative predictive value of 87.5% for high-risk NASH in the derivation sample.
In conclusion, for the authors, a score combining three ultrasound markers may be useful for non-invasive identification of patients with high-risk non-alcoholic steatohepatitis for inclusion in clinical trials and pharmacologic therapy.

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