Obese NAFLD children and adolescents: high BMI predicts liver fibrosis
This study aimed to investigate the predictors for liver fibrosis and the effects of short-term nutritional intervention on steatosis and fibrosis among obese..
Read More
NAFLD in the elderly
In this review, the authors provide an overview of considerations relevant to the management and diagnosis of NAFLD in older adults.
Read More
Diabetic kidney disease, cardiovascular disease and NAFLD
The aim of this review is “to raise awareness about the relationship of NAFLD, CVD and CKD in T2D patients and to improve our understanding and assessment of those conditions”.
Read More
FIB-4 and NFS: which performance?
The authors conducted a meta-analysis to assess the performance of the FIB-4 and NFS scores, the 2 most common non-invasive tools, for the appropriate selection of subjects with AF for biopsy.
Read More
Enhanced liver fibrosis test and recognition of liver fibrosis
This retrospective cross-sectional study was conducted among patients recruited from a large, community-based hospital system’s outpatient liver clinic from 2001 to 2020.
Read More
NAFLD unawareness in US adults
S. A. Alqahtani et al. (King Faisal Specialist Hospital and Research Centre, Saudi Arabia; Johns Hopkins University, USA) aimed to understand public awareness of NAFLD and its temporal trends.
They included 11,700 adults from five National Health and Nutrition Examination Surveys (2007-2016).
From 2007-2008 to 2015-2016, awareness of liver disease among adults with NAFLD improved from 4.4% to 6.3%, but 4 to 10 times lower than awareness about viral hepatitis. In 2015-2016, among
adults with NAFLD, awareness of liver disease was low among young adults and among non-Hispanic Blacks.
Nearly 96% of adults with NAFLD in the USA were unaware they had liver disease, especially among young adults and non-Hispanic Blacks.
Identifying patients with high-risk NASH: three ultrasound markers
Identifying patients with high-risk-NASH who are candidates for pharmacologic therapy remains a challenge. K. Sugimoto et al. (Tokyo Medical University, Japan) aimed to develop a score to identify patients with a NAFLD activity score of 4 or greater and clinically significant fibrosis.
In this cross-sectional study, the most predictive model combined three ultrasound markers: liver stiffness, attenuation coefficient, and dispersion slope. It showed a positive predictive value of 86.5% and a negative predictive value of 87.5% for high-risk NASH in the derivation sample.
In conclusion, for the authors, a score combining three ultrasound markers may be useful for non-invasive identification of patients with high-risk non-alcoholic steatohepatitis for inclusion in clinical trials and pharmacologic therapy.
Detection of HCC in patients with NAFLD
G. P. Caviglia et al. aimed to investigate the diagnostic accuracy of alpha-fetoprotein (AFP), protein induced by vitamin K absence or antagonist-II (PIVKA-II), glypican-3 (GPC-3), adiponectin, leptin and interleukin-6 (IL-6), alone or in combination, for the discrimination between NAFLD patients with or without HCC.
Read More
Imaging biomarkers of NAFLD, NASH, and fibrosis
In this review, V. Ajmera and R. Loomba critically examine the use of non-invasive imaging biomarkers to diagnose NAFLD, NASH, and fibrosis stage.
Read More
NAFLD: no liver biopsy in 2/3 patients of a real-world cohort
The aim of this study was to determine patient factors predictive of histologic versus empiric clinical diagnosis of NAFLD in real-world practice.
Read More