NASH Observatory

MM Asfari et al. aimed to evaluate the association between polycystic ovarian syndrome and NAFLD using a large national database. Adult female patients (≥18 years) with polycystic ovarian syndrome using the National Inpatient Sample database between 2002 and 2014. The control group included...

Hepatocellular carcinoma is the fifth and ninth most commonly diagnosed cancer in men and women, respectively, and the fourth leading cause of cancer mortality worldwide. Risk factors for HCC include chronic hepatitis B and hepatitis C, alcohol addiction, metabolic liver disease (particularly non-alcoholic fatty liver disease) and exposure...

Trimethylamine N-oxide (TMAO), choline and betaine serum levels have been associated with metabolic diseases including type 2 diabetes (T2D) and non-alcoholic fatty liver disease (NAFLD). These associations could be mediated by insulin resistance.However, the relationships among these metabolites, insulin resistance and NAFLD have...

In their review, F. Idalsoaga et al. (Departamento de Gastroenterología, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile) aim to summarise current data on the overlapping pathophysiology of NAFLD and alcohol-related fatty liver disease, the available information on alcohol consumption in patients with NAFLD...

NAFLD comprises a spectrum of progressive liver pathologies, ranging from simple steatosis to NASH, fibrosis, and cirrhosis. A liver biopsy is currently required to stratify high‐risk patients. Predicting the degree of liver inflammation and fibrosis using non‐invasive tests remains challenging...

V. Houttu et al. (Department of Experimental Vascular Medicine, University of Amsterdam, Amsterdam, The Netherlands) review the current literature on exercise and the gut microbiome in NAFLD. The human gut microbiome has been found to influence...

Physical inactivity and sedentary lifestyle have contributed to the epidemic of obesity and NAFLD. Moreover, NAFLD and sarcopenia have similar pathophysiological profiles. ZM Younossi et al. assessed the association between physical activity, NAFLD, and sarcopenia, and their contributions to mortality, using data from the National Health and Nutrition...

The results of randomized controlled trials (RCTs) investigating supplemental vitamin D on aminotransferases and cardio-metabolic risk factors in subjects with NAFLD have been inconsistent. A meta-analysis of randomized controlled trials by XF Guo et al. (Institute of Nutrition & Health, Qingdao University...

NAFLD and type 2 diabetes are closely associated phenomena. In contrast to the knowledge about NAFLD and type 2 diabetes, there are limited and inconsistent data on NAFLD prevalence in patients with type 1 diabetes mellitus. Type 1 diabetes and type 2 diabetes show major pathophysiological differences but share certain...

Serum gamma-glutamyl transferase (GGT) is a marker of oxidative stress, associated with increased cardiovascular risk. The impact of smoking on oxidative stress may be aggravated in individuals with NAFLD. ET Oni et al. (Cardiology Division, Heart and Vascular Institute, Einstein Medical Center, Philadelphia, PA, USA) aimed to...