The slide above illustrates the role of PPARα, PPARβ/δ and PPARγ as key regulators of lipid metabolism, inflammation and glucose metabolism. Understanding the role of various peroxisome proliferator-activated receptors and their ligands in clinical practice is very important for the future of NASH management. It illustrates why a “pan” PPAR approach can be beneficial and why more research is needed.
PPAR’s as Critical Regulators of Metabolism
Prof Roden, Germany explains why PPAR’s are interesting therapeutic targets not only to improve adipose tissue function but also for the liver. The approach can go beyond the improvement of liver function and aim at a more systemic approach with cardiovascular benefits.