Commented Articles

Physical activity and NAFLD have an inverse association. However, studies assessing the impact of the widely accepted Physical Activity Guidelines for Americans on NAFLD are lacking. D. Kim et al. (Stanford University School of Medicine, Stanford, USA) performed a serial, cross-sectional analysis among ...

Morbidity related to NAFLD and resulting NASH is likely to increase dramatically in the coming decades, especially in the Gulf countries, where there is already an epidemic of obesity and diabetes melittus. In their article, K. Alswat et al. (Liver Disease Research Center, College of Medicine, King Saud University, Riyad) estimated...

Manual histologic assessment is currently the accepted standard for diagnosing and monitoring disease progression in nonalcoholic steatohepatitis (NASH), but is limited by variability in interpretation and insensitivity to change. A. Taylor-Weiner et al. (PathAI, Boston, Massachusetts, USA) describe here a machine learning-based approach to liver...

Cardiovascular disease, rather than liver decompensation, remains the leading cause of morbidity and mortality in patients with NAFLD and NASH. A significant proportion of the cardiovascular risk in NASH is likely attributable to shared metabolic risk factors. Nevertheless, there is much interest in understanding the independent contribution...

The global prevalence of NAFLD is estimated at approximately 25%. In a recent meta-analysis on the global epidemiology of NAFLD, Younossi et al. reported the prevalence to be highest (32%) in the Middle East, and is estimated to grow further with an increase in its risk factors such as obesity, metabolic syndrome...

Although early stages of NASH may not be associated with severe symptoms, it is increasingly appreciated that NASH is not an asymptomatic disease. In fact, systematic assessments of patients with NASH using validated health-related quality- of-life instruments suggest significant impairment of patient-reported outcomes...

The aim of the current study by A. Mari et al. (Nazareth Hospital EMMS, Nazareth, and Faculty of Medicine in the Galilee, Bar-Ilan University, Safed, Israel) was to assess the impact of caloric restrictions during Ramadan fasting on severity index of NASH severity scores. The authors conducted a retrospective, case control study in Nazareth Hospital...

Non-invasive tests of NAFLD can be classified by the target disease state or the type of test. Disease states of interest include the detection of hepatic steatosis (for the diagnosis of NAFLD or using steatosis improvement as treatment outcomes in early phase studies)...

The spectrum that ranges from non-alcoholic fatty liver disease (NAFLD) to the more aggressive form of non-alcoholic steatohepatitis (NASH) all the way to liver cirrhosis is associated with complications and hepatocellular carcinoma. Extrahepatic malignancies are among the leading causes of death in patients with NAFLD, but little is known about...