Non-invasive tests of NAFLD can be classified by the target disease state or the type of test. Disease states of interest include the detection of hepatic steatosis (for the diagnosis of NAFLD or using steatosis improvement as treatment outcomes in early phase studies), NASH, and fibrosis. Types of tests include simple scores based on routine clinical and laboratory parameters, specific blood biomarkers, and imaging techniques.
This review by JW Wai et al. (The Chinese University of Hong Kong, Hong Kong, China) summaries the known and potential confounding factors that affect the performance of non-invasive tests of hepatic steatosis and fibrosis in patients with NAFLD.