Commented Articles

PanNASH covers commented articles ans publications to acquire sufficient information, understanding, and skills to cope with NASH/NAFLD healthcare demands.

Increased plasma XOR activity induced by NAFLD/NASH and its possible involvement in vascular neointimal proliferation

Authors: Kawachi Y, Fujishima Y, Nishizawa H, et al.
Published in JCI Insight 2021
Xanthine oxidoreductase is an enzyme that catalyses hypoxanthine to xanthine and xanthine to uric acid, respectively. However, the underlying mechanisms of increased plasma xanthine oxidoreductase and its pathological roles in systemic diseases, such as atherosclerosis, are not fully understood...
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Serum uric acid level and NAFLD in T2DM patients

Authors: Yu H, Zhao L, Liu L, et al.
Published in Medicine (Baltimore) 2021
This study aimed to investigate the association between serum uric acid level and NAFLD in 583 patients with type 2 diabetes (T2DM) hospitalised in the Department of Hepatology, Yantai Qishan Hospital (China). In this study, multivariate regression analyses demonstrated that after adjusting for confounding factors...
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Sugar and fat increase the risk of advanced liver disease

Authors: Manka P, Syn WK.
Published in Dig Dis Sci 2021
In this editorial, P. Manka Essen University Hospital, Germany) and W. K. Syn (Medical University of South Carolina, USA) comment a study by Benhammou and colleagues, who evaluated the effects of NAFLD risk factors including obesity and diabetes on the long-term outcomes of patients with HCV treated with direct-acting antivirals...
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Phytomedicines in experimental models of NAFLD

Authors: Ore A, Akinloye OA.
Published in Medicina (Kaunas) 2021
This systematic review aims to investigate the potential multi-targeting effects of plant-derived extracts in experimental models of NAFLD. The authors, A. Ore et al., (Ajayi Crowther University, Oyo, and Federal University of Agriculture, Abeokuta, Nigeria) identified 9 articles fulfilling their inclusion criteria...
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NAFLD and coronary artery calcium score

Authors: Chen CC, Hsu WC, Wu HM, et al.
Published in Medicina (Kaunas) 2021
This study by C. C. Chen et al. (Department of Family Medicine, Asia University Hospital, Taichung, Taiwan) investigated the association between NAFLD, diagnosed by ultrasonography, and coronary artery calcium score as detected by computed tomography in general populations in 545 patients...
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Liver organoid cultures and development of new therapeutic agents

Authors: Yamamoto H, Usui T, Sasaki K.
Published in Nihon Yakurigaku Zasshi 2021
In this review in Japanese, H. Yamamoto et al. (Tokyo University of Agriculture and Technology, Japan) outline the current issues in the diagnosis and treatment of NASH and introduce their research for the discovery of early diagnostic markers and the development of new therapeutic agents using liver organoid cultures derived from mouse models of NASH...
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Review: MAFLD prevalence in children and adolescents

Authors: Ramírez-Mejía MM, Díaz-Orozco LE, Barranco-Fragoso B, et al.
Published in Med Sci Monit 2021
MAFLD is the most common cause of chronic liver disease in children and adolescents. The risk factors for MAFLD may be prenatal, such as genetic factors, or postnatal, such as obesity and insulin resistance. MAFLD is increasingly recognized in children and adolescents...
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NASH and exposure to cigarette smoking

Authors: Fouda S, Khan A, Chan SMH, et al.
Published in Clin Sci (Lond) 2021
Consumption of diet rich in fat and cigarette smoking are independent risk factors of NASH and they often occur together in some populations. The present study by S. Fouda et al. (RMIT University, Melbourne, Australia) investigated the mechanisms of high fat diet and cigarette smoking, individually and in combination...
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NAFLD patients and PCI: In-hospital outcomes

Authors: Ali H, Kazmi M, Choi C, et al.
Published in Cureus 2021
This study by H. Ali et al. (Rutgers University New Jersey Medical School, USA) aims to explore outcomes in 429,855 patients who underwent percutaneous coronary intervention with or without placement of drug-eluting stents to determine whether the concurrent diagnosis of NAFLD led to worse in-hospital outcomes...
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Physical activity, cardiorespiratory fitness and NAFLD

Authors: Kerr CJ, Waterworth SP, Brodie D, et al.
Published in J Gastroenterol Hepatol 2021
High levels of physical activity and cardiorespiratory fitness may protect against NAFLD. C. J. Kerr et al. (University of Essex, UK) investigated whether different physical activity intensities, and cardiorespiratory fitness, were independent predictors of non-alcoholic fatty liver disease...
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