Commented Articles

PanNASH covers commented articles ans publications to acquire sufficient information, understanding, and skills to cope with NASH/NAFLD healthcare demands.

Discussing the prevalence of NAFLD in older patients with type 2 diabetes

Authors: Binet Q, Hermans MP, Lanthier N.
Published in Journal of Hepatology 2022
A 2022 study by Ajmera and colleagues examined the prevalence of non-alcoholic fatty liver disease (NAFLD), advanced fibrosis, cirrhosis, and hepatocellular carcinoma (HCC) in older patients with type 2 diabetes (T2D). The strong association between T2D, NAFLD, and its progressive form non-alcoholic steatohepatitis (NASH) has been extensively underscored by recent literature.
Read MoreDiscussing the prevalence of NAFLD in older patients with type 2 diabetes

Knowledge of NAFLD in Chinese young adults: a rationale for educational interventions?

Authors: Du Y, Su D, Ratnapradipa KL, et al.
Published in Published in: Journal of Cancer Education 2022
The prevalence of non-alcoholic fatty liver disease (NAFLD) in China has increased by 60% between 2000 and 2018. This trend is expected to intensify during the next decade. Chinese young adults (CYA) will thus be disproportionately burdened by NAFLD and its potential progression into hepatocellular carcinoma (HCC).
Read MoreKnowledge of NAFLD in Chinese young adults: a rationale for educational interventions?

The role of circadian clocks in the pathogenesis of NAFLD

Authors: Perez-Diaz-Del-Campo N, Castelnuovo G, Caviglia GP, et al.
Published in Nutrients 2022
The circadian clock controls rhythms responsible for regulating bodily functions, e.g., appropriate eating times. When this clock becomes disrupted due to factors such as irregular daily eating patterns or weekly schedules, it instead promotes lipid dysregulation, oxidative stress, and inflammation.
Read MoreThe role of circadian clocks in the pathogenesis of NAFLD

Neck circumference and ratios: a low-cost alternative for the assessment of steatosis?

Authors: Elorz M, Benito-Boilos A, Marin BA, et al.
Published in Nutrients 2022
Magnetic resonance imaging (MRI) is the most sensitive and specific non-invasive tool (NIT) for the evaluation and quantification of hepatic steatosis in patients with non-alcoholic fatty liver disease (NAFLD). However, it remains a relatively expensive tool, and is not routinely used in clinical practice.
Read MoreNeck circumference and ratios: a low-cost alternative for the assessment of steatosis?

The role of circadian clocks in the pathogenesis of NAFLD

Authors: Perez-Diaz-Del-Campo N, Castelnuovo G, Caviglia GP, et al.
Published in Nutrients 2022
The circadian clock controls rhythms responsible for regulating bodily functions, e.g., appropriate eating times. When this clock becomes disrupted due to factors such as irregular daily eating patterns or weekly schedules, it instead promotes lipid dysregulation, oxidative stress, and inflammation.
Read MoreThe role of circadian clocks in the pathogenesis of NAFLD

miRNAs: potential diagnostic biomarkers for NAFLD?

Authors: Konings M, Baumgartner S, Mensink RP, et al.
Published in Nutrients 2022
Recent reviews have highlighted the existence of an association between microRNAs (miRNAs) and non-alcoholic fatty liver disease (NAFLD). miRNAs have been linked to cholesterol metabolism, which is significantly dysregulated in NAFLD and leads to hepatic free cholesterol accumulation.
Read MoremiRNAs: potential diagnostic biomarkers for NAFLD?

The role of sex-based differences in NASH regulation

Authors: Kamiya A, Ida K.
Published in Cells 2022
Several recent studies have suggested the existence of a relationship between sex-based differences, liver injury, and cell survival in patients with non-alcoholic steatohepatitis (NASH). B cell lymphoma 6 (Bcl6), a nuclear transcription factor responsible for the regulation of sex-biased functional gene expression in the liver, has been linked to NASH.
Read MoreThe role of sex-based differences in NASH regulation

Explaining increased NAFLD prevalence in patients with mood disorders

Authors: Gangopadhyay A, Ibrahim R, Theberge K, et al.
Published in Frontiers in Neuroscience 2022
Strong clinical evidence exists to support the existence of an association between mental illness and non-alcoholic fatty liver disease (NAFLD). It is known that NAFLD is highly comorbid with psychiatric illness, and patients with bipolar disorder and schizophrenia possess increased prevalence of metabolic liver disease.
Read MoreExplaining increased NAFLD prevalence in patients with mood disorders

MAFLD: a relevant definition for cardiologists?

Authors: Zhou XD, Cai J, Targher G, et al.
Published in Cardiovascular Diabetology 2022
There is little awareness among cardiologists regarding the contribution of fatty liver to cardiovascular (CVD) risk. Debates surrounding the importance of screening for fatty liver disease compared to other recognized cardiometabolic risk factors are ongoing.
Read MoreMAFLD: a relevant definition for cardiologists?

Vigorous physical activity and reduced all-cause mortality: a significant association?

Authors: Henry A, Paik JM, Austin P, et al.
Published in Alimentary Pharmacology and Therapeutics 2022
Currently, the most effective treatment for non-alcoholic fatty liver disease (NAFLD) is diet and exercise. Weight loss of 5% achieved through lifestyle interventions has been associated with the reversal of steatosis, and a 10% weight reduction has been linked to the reversal of fibrosis. Physical activity (PA) has been hypothesised to reduce the accumulation of intrahepatic triglycerides contributing to NAFLD progression.
Read MoreVigorous physical activity and reduced all-cause mortality: a significant association?

The impact of exercise on hepatic liver droplets for the prevention and treatment of NAFLD

Authors: Yang Y, Li X, Liu Z, et al
Published in Nutrients 2022
Lipid droplets (LDs) are lipid-rich and dynamic organelles which undergo cycles of biogenesis (triacylglycerol synthesis, as well as LD growth, budding, and expansion) and degradation (lipophagy). Many studies have highlighted the causative role of abnormal LD accumulation in the development of non-alcoholic fatty liver disease (NAFLD). Furthermore, while the positive impact of physical activity on NAFLD has been widely studied, its effect on LD dynamics remains unclarified.
Read MoreThe impact of exercise on hepatic liver droplets for the prevention and treatment of NAFLD

Ultrasound-based methods for the diagnosis and staging of liver steatosis

Authors: Hari A
Published in Diagnostics 2022
Research in recent years has documented the rise of quantitative ultrasound-based examinations (qnUS) for the assessment of liver steatosis. qnUS of interest include continuous attenuation parameters (CAP), backscatter coefficients, and ultrasound envelope statistic parametric imaging. Despite the clear financial and patient-centric benefits of such non-invasive tools, their reliability in defining both the presence and degree of liver steatosis remains unclear.
Read MoreUltrasound-based methods for the diagnosis and staging of liver steatosis

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