PanNASH covers commented articles ans publications to acquire sufficient information, understanding, and skills to cope with NASH/NAFLD healthcare demands.
The term metabolic dysfunction-associated fatty liver disease (MAFLD) has recently been
suggested as an alternative to non-alcoholic fatty liver disease (NAFLD). Unlike NAFLD,
MAFLD’s diagnosis is based on the active identification of NAFLD-associated metabolic abnormalities. Many researchers agree that MAFLD adequately captures the systemic factors and upstream drivers of the disease, with a significant proportion concluding that it does so better than the original NAFLD definition.
Non-alcoholic fatty liver disease (NAFLD) has become the fastest growing cause of hepatocellular carcinoma (HCC) in the United States, Europe, and South-East Asia. HCC related to non-alcoholic steatohepatitis (NASH), the inflammatory subtype of NAFLD, may soon become as prominent worldwide as viral HCC.
Recent evidence has highlighted non-alcoholic steatohepatitis’ (NASH) predisposing role in the development of hepatocellular carcinoma (HCC). Despite this, the mechanisms underlying NASH-related HCC remain unknown. Identifying the molecular pathways contributing to the development of NASH-HCC is crucial to addressing this knowledge gap, and the determination of novel therapeutic targets for NASH-HCC remains a clinical priority.
A recent pilot study found that elderly individuals (over 65 years of age) with type 2 diabetes mellitus (T2DM) are at a significantly higher risk of developing NAFLD and advanced fibrosis. However, this finding requires further validation before systematic screening of this patient population can be recommended by practice guidelines.
Published in The Lancet Gastroenterology and Hepatology 2022
Dysfunctional visceral adipose tissue is one of the major drivers and determinants of non-alcoholic fatty liver disease (NAFLD). Due to an inability to store excess energy in adipose tissue compartments, the body resorts to storing it in ectopic fat compartments. Compared with lean individuals, people who are overweight or obese are thus at a higher risk of developing NAFLD.
Authors: Mózes FE, Lee JA, Anandraj Selvaraj A et al.
Published in Gut 2022
While liver biopsy is the current golden standard for the diagnosis and staging of fibrosis, many studies have highlighted the usefulness of non-invasive tests (NITs) for fibrosis screening and risk stratification. Despite this, pertinent NIT thresholds for these applications have yet to be defined.
Myeloid immune cells, e.g. macrophages, play a crucial role in the progression of non-alcoholic fatty liver disease (NAFLD), and thus significantly contribute to the development of non-alcoholic steatohepatitis (NASH). However, due to its complex phenotype and high heterogeneity, this cell type is particularly difficult to isolate and analyse.
Authors: Eslam M, El-Serag HB, Francque S, et al..
Published in Nature Reviews: Gastroenterology and Hepatology 2022
The term metabolic dysfunction-associated fatty liver disease (MAFLD) has recently been suggested as an alternative to non-alcoholic fatty liver disease (NAFLD). Unlike NAFLD, MAFLD’s diagnosis is based on the active identification of NAFLD-associated metabolic abnormalities. While MAFLD is commonly associated with obesity, recent evidence has affirmed that a significant proportion of MAFLD patients in fact possess normal body mass indexes (BMI).
The current gold standard for the diagnosis and assessment of non-alcoholic fatty liver disease (NAFLD) progression is liver biopsy, which is then followed by microscopic analysis by a pathologist.To assess disease progression, the Kleiner and Brunt scoring system is typically used. In short, this approach assesses three histological features of liver injury (ballooning, inflammation, and steatosis). Analyses of these features are then combined to generate a NAFLD activity score.
Authors: Meijnikman AS, Davids M, Herrema H, et al.
Published in Nature Medicine 2022
It has been hypothesised that ethanol produced by the gut microbiome may contribute to the development of non-alcoholic fatty liver disease (NAFLD). If ethanol is produced in clinically relevant amounts, it may affect lipid and glucose metabolism, which could prompt the development of steatosis and inflammation in the liver.
Published in Journal of Cachexia, Sarcopenia and Muscle 2022
The term metabolic dysfunction-associated fatty liver disease (MAFLD) has recently been suggested as an alternative to non-alcoholic fatty liver disease (NAFLD). Unlike NAFLD, MAFLD’s diagnosis is based on the active identification of NAFLD-associated metabolic abnormalities. Sarcopenia is defined as an age-related decline of skeletal muscle function and strength. It is also associated with a loss of muscle mass.
It is well-known that patients with non-alcoholic fatty liver disease (NAFLD) have an increased risk of all-cause, cardiovascular, and liver-related mortality. In addition to these adverse outcomes, patients with NAFLD often suffer from poor health-related quality of life, depression, and fatigue.
SUBSCRIBE TO OUR MONTHLY NEWSLETTER TO GET THE LATEST UPDATES
Manage your privacy
To provide the best experiences, we use technologies like cookies to store and/or access device information. Consenting to these technologies will allow us to process data such as browsing behavior or unique IDs on this site. Not consenting or withdrawing consent, may adversely affect certain features and functions.
Functional
Always active
The technical storage or access is strictly necessary for the legitimate purpose of enabling the use of a specific service explicitly requested by the subscriber or user, or for the sole purpose of carrying out the transmission of a communication over an electronic communications network.
Preferences
The technical storage or access is necessary for the legitimate purpose of storing preferences that are not requested by the subscriber or user.
Statistics
The technical storage or access that is used exclusively for statistical purposes.The technical storage or access that is used exclusively for anonymous statistical purposes. Without a subpoena, voluntary compliance on the part of your Internet Service Provider, or additional records from a third party, information stored or retrieved for this purpose alone cannot usually be used to identify you.
Marketing
The technical storage or access is required to create user profiles to send advertising, or to track the user on a website or across several websites for similar marketing purposes.
To provide the best experiences, we use technologies like cookies to store and/or access device information. Consenting to these technologies will allow us to process data such as browsing behavior or unique IDs on this site. Not consenting or withdrawing consent, may adversely affect certain features and functions.
Functional
Always active
The technical storage or access is strictly necessary for the legitimate purpose of enabling the use of a specific service explicitly requested by the subscriber or user, or for the sole purpose of carrying out the transmission of a communication over an electronic communications network.
Preferences
The technical storage or access is necessary for the legitimate purpose of storing preferences that are not requested by the subscriber or user.
Statistics
The technical storage or access that is used exclusively for statistical purposes.The technical storage or access that is used exclusively for anonymous statistical purposes. Without a subpoena, voluntary compliance on the part of your Internet Service Provider, or additional records from a third party, information stored or retrieved for this purpose alone cannot usually be used to identify you.
Marketing
The technical storage or access is required to create user profiles to send advertising, or to track the user on a website or across several websites for similar marketing purposes.