NASH: Bile acid profiling

Commentary

Bile acids synthesis and metabolism have been impaired in NASH patients because of liver injury, inflammation or obstruction of bile ducts. Changes in bile acids composition might contribute to NASH pathogenesis.

B. Kong et al. (Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, USA) “focus on the method for analysing individual bile acids profile in mouse biofluids and tissues by high-performance liquid chromatography coupled with ion trap mass spectrometry (HPLC-MS).”