Commentary
Development and severity of NAFLD have been linked to obesity and white adipose tissue dysfunction plays a key role in this relation. Ó. Osorio-Conles et al. (Instituto de Salud Carlos III, Institut d’Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain) compared the main features of subcutaneous and visceral white adipose tissue dysfunction in 48 obese women without and with NAFLD undergoing bariatric surgery and matched for age, BMI and T2D status.
Their data “support the existence of distinctive NAFLD signatures in white adipose tissue from women with severe obesity”.
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NASH: Bile acid profiling