Commentary
There are many complex physio-pathologic connections within the brain, gut, and liver axis. This review by E. Rebelos et al. (University of Turku, Finland) is focused on the early pathophysiology of brain, gut, and liver axis in the context of insulin resistance and specifically addresses two pillars of hepatic insulin resistance, namely dysregulated endogenous glucose production and MAFLD.
Specific emphasis is given to novel findings from imaging studies, in particular to positron emission tomography, a unique opportunity for the noninvasive in vivo study of tissue metabolism. The authors also discuss new insights that can be gained from targeted animal models in order to clarify what the available preclinical evidence suggests for the causal interactions between fatty liver, dysregulated endogenous glucose production and insulin resistance.
