Commented Articles

PanNASH covers commented articles ans publications to acquire sufficient information, understanding, and skills to cope with NASH/NAFLD healthcare demands.

Hepatic inflammatory responses in liver fibrosis

Authors: Hammerich L, Tacke F
Published in Nature reviews gastroenterology & hepatology
Recent technological advancements have provided unprecedented insights into the inflammatory mechanisms underlying liver fibrosis, leading to the identification of promising novel targets for anti-inflammatory and antifibrotic therapies.
Read MoreHepatic inflammatory responses in liver fibrosis

Screening, Diagnosis, and Staging of Non-Alcoholic Fatty Liver Disease (NAFLD): Application of Society Guidelines to Clinical Practice

Authors: Ilagan-Ying Y, Ilagan-Ying B et al
Published in Current Gastroenterology Reports (2023)
Metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as non-alcoholic fatty liver disease (NAFLD) has emerged as a leading cause of chronic liver disease, affecting a staggering 30% of the global population.
Read MoreScreening, Diagnosis, and Staging of Non-Alcoholic Fatty Liver Disease (NAFLD): Application of Society Guidelines to Clinical Practice

Surveying Stigma: MAFLD’s Nomenclature from Patient and Provider Perspectives

Authors: Younossi ZM et al.
Published in Journal of Hepatology (November 2023)
Non-alcoholic fatty liver disease (NAFLD) is estimated to affect 38% of adults worldwide, a statistic which is expected to increase with the rise of type 2 diabetes and obesity.
Read MoreSurveying Stigma: MAFLD’s Nomenclature from Patient and Provider Perspectives

Cardiovascular Disease in MASLD Patients: Mitigating Risks

Authors: Mellemkjær A et al.
Published in European Journal of Internal Medicine (November 2023)
The term metabolic dysfunction-associated steatotic liver disease (MASLD) has recently been proposed as an alternative to non-alcoholic fatty liver disease (NAFLD)’s exclusionary nomenclature.
Read MoreCardiovascular Disease in MASLD Patients: Mitigating Risks

Exploring the Promise of Pan-PPAR Agonism

Authors: Staels B, Butruille L, and Francque S
Published in Journal of Hepatology (November 2023)
Peroxisome proliferated-activated receptors (PPARs), including α, β/δ and γ isotypes, are a nuclear receptor family of lipid sensors activated by natural fatty acid derivatives and pharmacological agonists.
Read MoreExploring the Promise of Pan-PPAR Agonism

Advancing Fibrosis Imaging: An Evaluation of Radiotracer Efficacy

Authors: Eriksson O and Velikyan I
Published in Pharmaceuticals (November 2023)
Tissue fibrosis is induced by an excessive collagen deposition in organs suffering from inflammation and is associated with several diseases, including non-alcoholic steatohepatitis (NASH).
Read MoreAdvancing Fibrosis Imaging: An Evaluation of Radiotracer Efficacy

Global research on fatty liver disease: a review

Authors: Lazarus JV, Mark HE, Allen AM, et al.
Published in J Hepatol (September 2023)
In this study, a large, global, multidisciplinary panel discussed priorities within the field of fatty liver disease, including its burden, policies surrounding the issue and treatment options.
Read MoreGlobal research on fatty liver disease: a review

Managing Hepatocellular Carcinoma in NAFLD: a review

Authors: Cadar R, Lupascu Ursulescu C, Vasilescu AM, et al
Published in Life (Basel) (September 2023)
Currently, there are rising levels of non-alcoholic fatty liver disease (NAFLD). With this, comes a concurrent increase in hepatocellular carcinoma (HCC) cases.
Read MoreManaging Hepatocellular Carcinoma in NAFLD: a review

The new paradigm of cardiometabolic syndrome: a review

Authors: Khan AR, Salama AH, Aleem Z, et al.
Published in Cureus (September 2023)
Cardiometabolic syndrome (CMS) involves a complex interplay of many issues, involving obesity, metabolic dysregulation, cardiovascular disease, insulin resistance and more. This condition extends to clinical implications including non-alcoholic fatty liver disease (NAFLD) as well as cancer and sleep apnoea.
Read MoreThe new paradigm of cardiometabolic syndrome: a review

Machine Learning Models for the Detection of (At-Risk) NASH: Unravelling the Potential

Authors: Lee J, Westphal M, Vali Y et al.
Published in Hepatology (July 2023)
Despite its health complications and inherent intra- and inter-observer variability, liver biopsy remains the gold standard for the detection of non-alcoholic steatohepatitis (NASH).
Read MoreMachine Learning Models for the Detection of (At-Risk) NASH: Unravelling the Potential

Discerning sex-related differences in NAFLD patients via metabolic profiling

Authors: Fotakis C, Kalafi IP, Amanitidou AI et al.
Published in Frontiers in Endocrinology (October 2023)
Research into personalised medicine for non-alcoholic fatty liver disease (NAFLD) underscores the importance of acknowledging NAFLD patients’ unique clinical phenotypes when developing targeted pharmacotherapies.
Read MoreDiscerning sex-related differences in NAFLD patients via metabolic profiling

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