Dr. G. Bozet, MD, Author At PanNASH

NASH Observatory Commented Articles

Endolysosomal network and MAFLD

Emerging evidence has shown that the endolysosomal network is crucial to maintain metabolic homeostasis. In this review, D. Y. Vos et al. summarise the current understanding of the role of the endolysosomal network in cholesterol homeostasis and its implications in MAFLD pathogenesis....

November 15, 2021

NASH Observatory Commented Articles

A link between hyperuricemia and NAFLD

An elevated level of plasma uric acid has been widely recognised as a risk factor for NAFLD, where oxidative stress and inflammation play an important role in the pathophysiology of the disease. Although the complete molecular mechanisms involved remain unknown, while under physiological conditions uric acid presents antioxidant properties...

November 10, 2021

NASH Observatory Commented Articles

NAFLD risk factors after antiviral treatment for hepatitis C

J. N. Benhammou et al. (University of California Los Angeles, and VA Greater Los Angeles Healthcare System, USA) aimed to determine whether diabetes and/or obesity are associated with adverse outcomes in direct-acting antiviral-treated HCV patients...

November 8, 2021

NASH Observatory Commented Articles Comorbidities Articles

Serum uric acid level and NAFLD in T2DM patients

This study aimed to investigate the association between serum uric acid level and NAFLD in 583 patients with type 2 diabetes (T2DM) hospitalised in the Department of Hepatology, Yantai Qishan Hospital (China). In this study, multivariate regression analyses demonstrated that after adjusting for confounding factors...

November 4, 2021

Management Articles Commented Articles NASH Observatory

Phytomedicines in experimental models of NAFLD

This systematic review aims to investigate the potential multi-targeting effects of plant-derived extracts in experimental models of NAFLD. The authors, A. Ore et al., (Ajayi Crowther University, Oyo, and Federal University of Agriculture, Abeokuta, Nigeria) identified 9 articles fulfilling their inclusion criteria...

November 2, 2021

Management Articles Commented Articles NASH Observatory

Liver organoid cultures and development of new therapeutic agents

In this review in Japanese, H. Yamamoto et al. (Tokyo University of Agriculture and Technology, Japan) outline the current issues in the diagnosis and treatment of NASH and introduce their research for the discovery of early diagnostic markers and the development of new therapeutic agents using liver organoid cultures derived from mouse models of NASH...

October 27, 2021

NASH Observatory Commented Articles Comorbidities Articles

NASH and exposure to cigarette smoking

Consumption of diet rich in fat and cigarette smoking are independent risk factors of NASH and they often occur together in some populations. The present study by S. Fouda et al. (RMIT University, Melbourne, Australia) investigated the mechanisms of high fat diet and cigarette smoking, individually and in combination...

October 25, 2021

NASH Observatory Commented Articles Comorbidities Articles

NAFLD patients and PCI: In-hospital outcomes

This study by H. Ali et al. (Rutgers University New Jersey Medical School, USA) aims to explore outcomes in 429,855 patients who underwent percutaneous coronary intervention with or without placement of drug-eluting stents to determine whether the concurrent diagnosis of NAFLD led to worse in-hospital outcomes...

October 21, 2021

NASH Observatory Commented Articles

Meta-analysis: coffee consumption and NAFLD

This meta-analysis by U. Hayat et al. (University of Kansas School of Medicine, USA) summarizes available literature about the protective impact of coffee consumption on NAFLD and liver fibrosis. This meta-analysis revealed a 23% decreased risk of development of NAFLD among patients who drank coffee regularly...

October 14, 2021

Commented Articles Pathophysiology Articles

NAFLD and hepatic sexual dimorphism

This review by Philippe Lefebvre and Bart Staels (INSERM, CHU Lille, Institut Pasteur de Lille, France) discusses the accumulating evidence of sexual dimorphism in NAFLD. Liver pathophysiology is sexually dimorphic, and male individuals predominantly show more severe stages of non-alcoholic fatty liver, NASH and fibrosis than do female individuals...

October 12, 2021

Commented Articles Comorbidities Articles

NAFLD prevalence in Type 1 diabetes patients

The authors reviewed and screened references in order to estimate NAFLD prevalence in patients with type 1 diabetes, and to explore associated characteristics and outcomes. According to this review, NAFLD prevalence in patients with type 1 diabetes is considerable and is highly dependent on the specific diagnostic modality...

September 22, 2021

Management Articles Commented Articles Ppar Articles

Emerging drugs targeting specific points in NASH pathogenesis

Extensive research and revelation in the field of pathogenesis of NASH has offered new possibilities of treatment and emerging new drugs that are being tested currently in numerous preclinical and clinical trials. These drugs target almost all steps in the pathogenesis of NASH...

September 20, 2021