Obese and overweight children: screening for early diagnosis of NAFLD is essential
NAFLD is increasingly recognised in obese and overweight children. In this cross-sectional study, S. Thiagarajan et al. (Indira Gandhi Medical College and Research Institute, India) aimed to assess the prevalence of NAFLD in this population and to identify the associated....
Weight-loss alone may not be sufficient to reverse advanced fibrosis
R. Pais et al. (Hôpital Pitié-Salpêtrière, Paris, France) describe the histological outcome in patients with advanced NASH and its relationship with weight loss and metabolic improvement after bariatric surgery. For the authors, “while bariatric surgery successfully...
Advanced NAFLD: measuring microRNA in a blood sample
MicroRNA levels in blood may change in liver disease including NAFLD. K. Johnson et al. (Newcastle University, UK) carried out microRNA sequencing in a group of 183 patients with NAFLD. One particular microRNA miR-193a-5p consistently increased...
NAFLD and MAFLD as emerging causes of hepatocellular carcinoma
Hepatocellular carcinoma is the most common type of liver cancer, increasingly arising in patients with NAFLD or MAFLD. S. Myers et al. (University of Geneva, Switzerland) assessed all patients with hepatocellular carcinoma between 1990 and 2014 in the canton of Geneva....
Non-obese MAFLD is associated with colorectal adenoma
Colorectal adenoma is linked to metabolic dysfunction. S. Fukunaga et al. (Kurume University School of Medicine, Japan) aimed to investigate the impact of MAFLD on the prevalence of colorectal adenoma by comparing it to NAFLD in health check-up examinees in a multicenter retrospective study....
NASH: bariatric surgery and major adverse liver and cardiovascular outcomes
In this retrospective cohort study of 1158 patients with biopsy-proven fibrotic NASH without cirrhosis, bariatric surgery was significantly associated with a lower risk of major adverse liver outcomes and major adverse cardiovascular events. For the authors, in this study....
NAFLD: progressive liver fibrosis
The progression of NASH was initially defined according to a two-hit model involving an initial development of steatosis, followed by a process of lipid peroxidation and inflammation. In contrast, current evidence proposes a "multi-hit" or "multi-parallel hit" model that includes multiple pathways....
Advancing the global public health agenda for NAFLD
In this global Delphi study, a multidisciplinary group of experts developed consensus statements and recommendations. The resulting consensus statements and recommendations address a broad range of topics that have general relevance for policymakers, health-care practitioners, civil society groups, research institutions....
Major depressive disorder and NAFLD: the interaction mechanisms
Testing the correlation between MDD and NAFLD, as they mediate and promote each other, gradually forming a vicious circle in patients...
Diet, physical activity, education level and NAFLD risk
In this cross-sectional analysis of the National Health and Nutrition Examination Surveys, 2017-2018, E. Vilar-Gomez et al. (University School of Medicine, USA) examined the association between diet quality, physical activity, socioeconomic status, and NAFLD risk...
NAFLD and CV disease among US adults
In this study, S. Ciardullo et al. (Università degli Studi di Milano Bicocca, Italy) present a population-based cross-sectional study including 2734 US adults using data from the 2017-2018 cycle of the National Health and Nutrition Examination Survey The authors show that “patients with NAFLD have....
NAFLD: recent guideline updates
In this review, Yumi Ando and Janice H. Jou (Portland, OR, USA) summarise updated guidelines and guidance recommendations for the management of adult NAFLD. Interestingly, the authors highlight key difference between US, Asian, and European recommendations; and provide key updates....