Dr. D. Beard, Author At PanNASH

NASH Observatory Commented Articles Comorbidities Articles

NAFLD and severe fibrosis are associated with to a high CV risk profile

G. Pennisi et al. (Università di Palermo, Italy) aimed to evaluate the impact of fatty liver and fibrosis on cardiovascular risk in a general population. They recruited 542 subjects included in the community-based ABCD (Alimentazione, Benessere Cardiovascolare e Diabete) study...

June 9, 2021

NASH Observatory Commented Articles

NIS4 for non-invasive diagnosis of NASH and liver fibrosis

S. A. Harrison et al. (University of Oxford, UK) report the development and validation of a blood-based diagnostic test to non-invasively rule in and rule out at-risk NASH. In their prospective derivation and global validation study, derivation was done in the discovery cohort, which comprised 239 prospectively recruited patients with...

June 2, 2021

NASH Observatory Commented Articles

NAFLD is significantly related to non-achievement of LDL cholesterol targets

To reduce cardiovascular disease (CVD) risk as much as possible, current guidelines recommend optimising LDL cholesterol management based on an individual’s CVD risk level. The risk of CVD among NAFLD patients is likely to be higher than it is in...

May 31, 2021

NASH Observatory Commented Articles

Patients with biopsy proven NAFLD: a significantly increased cancer incidence

Recent studies link NAFLD to an increased incidence of hepatocellular carcinoma (HCC) and extrahepatic cancers. However, prior studies were small or lacked liver histology, which remains the gold standard for staging NAFLD severity. TG Simon et al...

May 27, 2021
Cancers

NASH Observatory Commented Articles Epidemiology Articles

NAFLD progression rates: a real-world analysis

The aim of this study by R. Loomba et al. (NAFLD Research Center, University of California, San Diego, USA) was to evaluate the impact of disease severity, demographics and comorbidities on risk of mortality and time to progression in a large, real-world cohort of diagnosed NAFLD patients...

May 25, 2021

NASH Observatory Commented Articles

Statin use among patients with NAFLD

Patients with NAFLD are at an increased risk of cardiovascular disease. Statins reduce the risk of cardiovascular events. Studies have shown statins are safe among patients with liver disease. Despite these data, statins are under prescribed among patients with liver disease due to concerns about hepatotoxicity. This study aimed to assess prevalence...

May 20, 2021

NASH Observatory Commented Articles Epidemiology Articles

Prevalence trends in NAFLD according to the Global Burden of Disease study

This study comprehensively investigated temporal trends in NAFLD prevalence at the global, regional, and national levels. The study included 21 regions and 195 countries or territories. The authors assessed secular trends in NAFLD risk factors, according...

May 17, 2021

NASH Observatory Commented Articles

Liver injury in COVID-19

The COVID-19 pandemic due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has posed a serious threat to global public health. Although primarily, the infection causes lung injury, liver enzyme abnormalities have also been reported to occur during the course of the disease. P. Anirvan et al. (Sriram Chandra Bhanj Medical College, Odisha, India) conducted...

May 10, 2021

Management Articles Commented Articles NASH Observatory

Is Europe ready to meet the challenge of fatty liver disease?

NAFLD is closely associated with obesity, metabolic syndrome, and diabetes. NAFLD can be optimally managed through a multidisciplinary patient-centred approach. National preparedness to address NAFLD is essential to allow for effective public health measures. NAFLD preparedness means having adequate policies and civil society...

May 5, 2021

NASH Observatory Commented Articles

Premenopausal NAFLD women: testosterone is associated with NASH and fibrosis

The association of free testosterone with NASH was determined in pre-menopausal women with biopsy-confirmed NAFLD. Interaction testing was performed for age and free testosterone given decline in testosterone with age, and association of aging with...

May 3, 2021

NASH Observatory Commented Articles

Randomized Control Trial: Fecal microbiota transplantation in NAFLD patients

The gut microbiome plays a role in metabolism and maintaining gut barrier integrity, and fecal microbiota transplantation can be used to alter the gut microbiome. The authors hypothesized that a fecal microbiota transplantation from a thin and healthy donor given to patients with NAFLD...

April 25, 2021

NASH Observatory Commented Articles

Perils of the western diet

NAFLD and hepatocellular carcinoma are strongly associated with obesity, insulin resistance and the metabolic syndrome and directly attributed to changes in lifestyle, especially dietary patterns and sedentary behaviour. Western diet and cholesterol contained in the diet exacerbate hepatic accumulation of free cholesterol, resulting in the toxic effects on the liver...

April 19, 2021