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Dr. D. Beard

DR. D. BEARD is specialist of Nash Pathology
  • Articles: 191
Videos & Slides: 0

Thyromimetics as emerging therapeutic agents for nonalcoholic steatohepatitis: rationale for the development of resmetirom (MGL-3196).

Hypothyroidism has been linked to certain elements of the metabolic syndrome such as obesity and dyslipidemia which may explain its association with NAFLD. The pathogenesis of NAFLD might be partly attributed to a state of relative intra-hepatic hypothyroidism, a condition of decreased liver thyroid hormone levels. Although...
Read MoreThyromimetics as emerging therapeutic agents for nonalcoholic steatohepatitis: rationale for the development of resmetirom (MGL-3196).

Diet quality and its association with nonalcoholic fatty liver disease and all-cause and cause-specific mortality.

Healthy diet has been recommended for NAFLD, although it is not clear whether improving diet quality can prevent mortality. ER Yoo et al. aim to assess the impact of quality of diet on NAFLD and mortality in subjects with and without NAFLD. High diet quality was inversely associated with NAFLD and was positively associated...
Read MoreDiet quality and its association with nonalcoholic fatty liver disease and all-cause and cause-specific mortality.

A Cross-Sectional Study of the Public Health Response to NAFLD in Europe

In 2018 and 2019, NAFLD experts in 29 European countries completed an English-language survey on policies, guidelines, awareness, monitoring, diagnosis and clinical assessment in their country. The data were compiled, quality checked against existing official documents and reported descriptively...

Read MoreA Cross-Sectional Study of the Public Health Response to NAFLD in Europe

Diagnostic Accuracy of Shear Wave Elastography as a Non-invasive Biomarker of High-Risk Non-alcoholic Steatohepatitis in Patients with Non-alcoholic Fatty Liver Disease.

In this study, A. Ozturk et al. (Center for Ultrasound Research & Translation, Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts, USA) evaluated the diagnostic accuracy of shear wave elastography for differentiating high-risk NASH from non-alcoholic fatty liver and low-risk NASH. One hundred sixteen adult patients underwent liver...
Read MoreDiagnostic Accuracy of Shear Wave Elastography as a Non-invasive Biomarker of High-Risk Non-alcoholic Steatohepatitis in Patients with Non-alcoholic Fatty Liver Disease.

Microbiome as a therapeutic target in alcohol-related liver disease.

Alcohol-related liver disease is associated with significant changes in gut microbial composition. Treatment approaches on the gut microbiota, such as diet, probiotics, antibiotics and faecal microbial transplantation can restore intestinal homeostasis and improve alcohol-related liver disease (1). Dysbiosis of the intestinal microbiota...
Read MoreMicrobiome as a therapeutic target in alcohol-related liver disease.

Prognostic value of non-alcoholic fatty liver disease in the elderly patients

There is very little information about NAFLD in the geriatric patients. V. Tallarico et al. (Division of Internal Medicine, University of Bologna, S. Orsola-Malpighi Hospital, Bologna, Italy) investigated the independent prognostic value of NAFLD on overall mortality in the elderly. 804 subjects were followed up for mortality for a median...
Read MorePrognostic value of non-alcoholic fatty liver disease in the elderly patients

Flaxseed oil in the context of a weight loss program ameliorates fatty liver grade in patients with non-alcoholic fatty liver disease: a randomized double-blind controlled trial

Long-chain omega-3 fatty acids have shown to regulate lipid metabolism and reduce fat accumulation in the liver. Masoumeh Akhlaghi et al. (Nutrition Research Center, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran) investigated the effect of flaxseed oil, as a rich source...

Read MoreFlaxseed oil in the context of a weight loss program ameliorates fatty liver grade in patients with non-alcoholic fatty liver disease: a randomized double-blind controlled trial

Diet and Non-Alcoholic Fatty Liver Disease: The Mediterranean Way

Nowadays, the cornerstone in the clinical management of NAFLD includes two easy and pivotal concepts that are: dietary modification associated with improvement of physical activity. In the era of evidence-based medicine, for L. Abenavoli et al. (Department of Health Sciences, University “Magna Graecia”, Catanzaro, Italy)...
Read MoreDiet and Non-Alcoholic Fatty Liver Disease: The Mediterranean Way

Applying Non-Invasive Fibrosis Measurements in NAFLD/NASH: Progress to Date.

To date, histological assessment of the liver using liver biopsy has served as the reference standard for evaluation of the presence and severity of NAFLD as well as for the assessment of disease progression or regression. Non-invasive tests to evaluate fibrosis rely on either changes in the physical properties...
Read MoreApplying Non-Invasive Fibrosis Measurements in NAFLD/NASH: Progress to Date.