Diet is considered as one of the main drivers to modulate the composition of gut microbiota, which participate in different processes, affecting human metabolism. A disruption in the homeostasis of gut microbiota may lead to dysbiosis, i.e. a reduction of the beneficial species and an increment in pathogenic microbiota.
S. Quesada-Vázquez et al. (Unitat de Nutrició i Salut, Centre Tecnològic de Catalunya, Reus, Spain) highlight the association between diet, gut microbiota and liver, and how this axis may promote the development of NAFLD progression. Gut dysbiosis and bacterial translocation in combination with a Western diet and lifestyle with inflammasome dysfunction lead to NAFLD progression. This dysbiosis produces an increase in harmful bacteria and/or a decrease in beneficial bacteria, affecting the health of both the intestine and the liver.