Commentary
It is estimated that there are more than 10 million NAFLD patients in Japan. 10-20% of NASH patients will progress to liver cirrhosis and 2-3% of them will develop hepatocellular carcinoma per year.
In their review, H. Nishikawa et al. (Osaka Medical and Pharmaceutical University, Takatsuki, and Hyogo College of Medicine, Japan) comprehensively summarise the current knowledge with regard to the relationship between obesity and HCC in Japan.
Hepatic inflammatory responses in liver fibrosis