Natural history & clinical outcomes in adults with NAFLD

Dr. Kris Kowdley explains the natural history and clinical outcomes in adults with non -alcoholic fatty liver disease (NAFLD) with lessons from cohort studies and placebo arms of trials. The take home points are that the natural history of NAFLD is variable. Further, the placebo response varies according to trial length, regression to mean as well as sample size. Advanced fibrosis (F3/F4) drives clinical outcomes in non-alcoholic steatohepatitis (NASH) with very high hazard ratios in decompensation and mortality in patients with F4 Fibrosis compared to those with earlier stages of fibrosis.