NASH Observatory

⏿ The PanNASH Initiative is an interactive web-based platform presenting global NASH statistics to inform NASH control and research.

Fatty Liver Index: A Hypertension Predictor in a South Korean Cohort

Although there can be common pathogenic mechanisms for NAFLD and hypertension associated with the development of cardiovascular diseases, little data are showing the association between NAFLD and hypertension in a large-scale cohort study. JH Roh et al. (department of cardiology in internal medicine, Chungnam National University Hospital, Daejeon, Korea)...

Read MoreFatty Liver Index: A Hypertension Predictor in a South Korean Cohort

Establishment of a Risk Prediction Model for Non-alcoholic Fatty Liver Disease in Type 2 Diabetes

The aim of this retrospective cohort study was to develop a risk nomogram for NAFLD in a Chinese population with T2DM. A questionnaire survey, physical examination and biochemical indicator testing were performed on 874 patients with T2DM...
Read MoreEstablishment of a Risk Prediction Model for Non-alcoholic Fatty Liver Disease in Type 2 Diabetes

Characterization and Proteome of Circulating Extracellular Vesicles as Potential Biomarkers for NASH

For many years, double-layer phospholipid membrane vesicles, released by most cells, were not considered to be of biological significance. This stance has dramatically changed with the recognition of extracellular vesicles (EVs) as carriers of biologically active molecules that can traffic to local or distant targets and execute defined biological functions...
Read MoreCharacterization and Proteome of Circulating Extracellular Vesicles as Potential Biomarkers for NASH

Left ventricular diastolic dysfunction in liver transplantation: a stronger association with non-alcoholic steatohepatitis

Cardiovascular death is an important cause of mortality in end stage liver disease patients undergoing orthotopic liver transplant. Left ventricular diastolic dysfunction is often the early manifestation of cirrhotic cardiomyopathy. In order to understand the risk factors for ventricular diastolic dysfunction in end stage liver disease patients...
Read MoreLeft ventricular diastolic dysfunction in liver transplantation: a stronger association with non-alcoholic steatohepatitis

Determining the reliability of liver biopsies in NASH clinical studies

The topic of liver biopsy in clinical studies, such as for treatments for NASH, is highly important. Despite limitations, liver biopsy remains the gold standard for the study of liver disease. It is important for the exclusion of alternative diseases and co-morbidities such as autoimmune hepatitis or primary biliary cholangitis...
Read MoreDetermining the reliability of liver biopsies in NASH clinical studies

The effect of coffee consumption on the non-alcoholic fatty liver disease and liver fibrosis: a meta-analysis of eleven epidemiological studies

Coffee consumption may have a protective impact on NAFLD and liver fibrosis. However, the evidence from the previous studies is inconsistent. This study comprises two meta-analyses. The first meta-analysis summarizes the effect of coffee consumption on NAFLD in patients who did or did not drink coffee...
Read MoreThe effect of coffee consumption on the non-alcoholic fatty liver disease and liver fibrosis: a meta-analysis of eleven epidemiological studies

Fructose stimulated de novo lipogenesis is promoted by inflammation

Excessive fructose intake causes dysbiosis and tight-junction proteins downregulation, resulting in intestinal-barrier deterioration and low-grade endotoxaemia. Fructose consumption stimulates hepatosteatosis and, when combined with other risk factors, can cause steatohepatitis and even hepatocellular carcinoma. It is well established...
Read MoreFructose stimulated de novo lipogenesis is promoted by inflammation

Physical Activity, Measured Objectively, is Associated With Lower Mortality in Patients With Nonalcoholic Fatty Liver Disease

D. Kim et al. (Stanford University School of Medicine, Stanford, California, United States) studied whether physical activity, measured by accelerometer, is associated with all-cause and cardiovascular mortality among individuals with NAFLD.

Read MorePhysical Activity, Measured Objectively, is Associated With Lower Mortality in Patients With Nonalcoholic Fatty Liver Disease