MAFLD might be considered as a multisystem disease that affects not only the liver but involves wider implications, relating to several organs and systems, the brain included.
The present study by S. Nucera et al. (University Magna Graecia of Catanzaro, Italy) aims to investigate changes associated with MAFLD-induced alteration of thalamic metabolism in vivo.
The experimental results suggest that thalamic energy metabolism is affected by MAFLD progression. This metabolic imbalance “might cause structural damage to brain cells and dysfunctions of neurotransmitter release.”