Chronopharmacology, or timing of drug administration in NASH

Commentary

Liver homeostasis is strongly influenced by the circadian clock. Disruption of the clock has been heavily implicated in the pathogenesis of NAFLD and NASH. There has been little consideration of the application of chronopharmacology in NASH, a strategy whereby the timing of drug delivery is informed by biological rhythms in order to maximise efficacy and tolerability.

The authors describe the potential for chronopharmacology in NASH and encourage greater consideration of the timing of drug administration in the design of future clinical trials.