Commentary
In this review, C. Engelmann C and F. Tacke (Campus Virchow-Klinikum and Campus Charité Mitte, Charité-Universitätsmedizin Berlin, Germany) critically discuss the currently existing evidence for the involvement of cellular senescence in NAFLD in order to identify areas requiring further exploration.
In summary, “there are substantial data suggesting that senescence plays an important role in NAFLD development and disease progression.” Several markers of senescence are linked with fat accumulation, inflammation and fibrogenesis.
