Weight-loss alone may not be sufficient to reverse advanced fibrosis

Commentary

R. Pais et al. (Hôpital Pitié-Salpêtrière, Paris, France) describe the histological outcome in patients with advanced NASH and its relationship with weight loss and metabolic improvement after bariatric surgery.

For the authors, “while bariatric surgery successfully reverses active steatohepatitis, advanced fibrosis can persist for many years and is associated with lesser weight-loss and metabolic improvement. Weight-loss alone may not be sufficient to reverse advanced fibrosis.”